Researchers here demonstrate that the GrimAge and GrimAge2 epigenetic clocks beat out other clocks while performing more or less equivalently to one another when it comes to predicting mortality in a novel study population. The higher a patient’s epigenetic age relative to their chronological age, the higher the risk of future mortality. Epigenetic clock results are not actionable, however. Since researchers do not yet understand how the specific epigenetic marks incorporated into the clock algorithm correlate with mechanisms of age-related dysfunction and disease, they cannot describe why a result is bad or good, nor inform any action taken in response. So at the present time it doesn’t matter what an epigentic clock result looks like – one should seek to improve…
GrimAge and GrimAge2 Clocks Perform Similarly in Predicting Mortality
Researchers here demonstrate that the GrimAge and GrimAge2 epigenetic clocks beat out other clocks while performing more or less equivalently to one another when it comes to predicting mortality in a novel study population. The higher a patient’s epigenetic age relative to their chronological age, the higher the risk of future mortality. Epigenetic clock results are not actionable, however. Since researchers do not yet understand how the specific epigenetic marks incorporated into the clock algorithm correlate with mechanisms of age-related dysfunction and disease, they cannot describe why a result is bad or good, nor inform any action taken in response. So at the present time it doesn’t matter what an epigentic clock result looks like – one should seek to improve…