Source https://www.fightaging.org/archives/2025/07/reviewing-cellular-senescence-in-skeletal-disease/
The evidence is compelling for the age-related accumulation of senescent cells to be an important driving mechanism of degenerative conditions in bone tissue. As for many other age-related conditions, animal study data suggests that clearance of senescent cells via the use of senolytic therapies is a promising form of treatment for age-related dysfunction in bone tissue. Human data is arriving only slowly, and initially only in small clinical trials more focused on safety than efficacy. Few trials are being conducted for the first generation, low-cost senolytics such as the dasatinib and quercetin …
Source https://www.fightaging.org/archives/2025/07/reviewing-cellular-senescence-in-skeletal-disease/
The evidence is compelling for the age-related accumulation of senescent cells to be an important driving mechanism of degenerative conditions in bone tissue. As for many other age-related conditions, animal study data suggests that clearance of senescent cells via the use of senolytic therapies is a promising form of treatment for age-related dysfunction in bone tissue. Human data is arriving only slowly, and initially only in small clinical trials more focused on safety than efficacy. Few trials are being conducted for the first generation, low-cost senolytics such as the dasatinib and quercetin …
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