Mesaconic Acid as a Beneficial Metabolite Generated in the Gut Microbiome of Centenarians

Source https://www.fightaging.org/archives/2025/08/mesaconic-acid-as-a-beneficial-metabolite-generated-in-the-gut-microbiome-of-centenarians/

A good deal of research interest is now focused on the composition of the gut microbiome as either (a) a contributing factor in degenerative aging, due to changes that take place with age or (b) a factor in determining natural variations in human life span. For example, a number of research groups have mapped the composition of gut microbiomes in very long-lived individuals. The study here goes a little beyond a map of species and relative population sizes to identify a metabolite produced by microbes that appears to be protective in older individuals, based on results in mice.

The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We p…

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