Source https://www.fightaging.org/archives/2025/10/first-xenotransplantation-of-a-genetically-engineered-pig-liver-into-a-human-volunteer/
It remains to be seen as to whether xenotransplantation of organs from genetically engineered pigs will be competitive in comparison to the tissue engineering of new organs. Even given the challenges faced to date, it seems likely that xenotransplanation will be a going concern before the manufacture of viable tissue engineered organs. Initial trials in patients volunteers have taken place for the heart and kidney. As the report here illustrates, the last mile of discovery in which pig organs are transplanted into the first volunteers is likely to require as much work and reveal as many unforeseen issues as was the case for the earlier stages of development, in which the need for genetic engineering of the donor pigs was discovered.
<blockquo…
Source https://www.fightaging.org/archives/2025/10/first-xenotransplantation-of-a-genetically-engineered-pig-liver-into-a-human-volunteer/
It remains to be seen as to whether xenotransplantation of organs from genetically engineered pigs will be competitive in comparison to the tissue engineering of new organs. Even given the challenges faced to date, it seems likely that xenotransplanation will be a going concern before the manufacture of viable tissue engineered organs. Initial trials in patients volunteers have taken place for the heart and kidney. As the report here illustrates, the last mile of discovery in which pig organs are transplanted into the first volunteers is likely to require as much work and reveal as many unforeseen issues as was the case for the earlier stages of development, in which the need for genetic engineering of the donor pigs was discovered.
<blockquo…
Source https://www.fightaging.org/archives/2025/10/introducing-naked-mole-rat-cgas-into-mice-and-flies-to-improve-dna-repair-and-treat-aging/
Naked mole-rats live as much as nine times longer than similarly sized rodent species, suffer little age-related decline of function until very late life, and there are next to no examples of individuals in captivity suffering from cancer. Researchers have spent more than twenty years investigating the biochemistry of this species, in search of the reasons for their longevity and resistance to cancer. As for other areas of the study of the comparative biology of aging, the hope is that some of these findings could form the basis for therapies to treat cancer and slow aging in humans. Whether this is the case remains to be seen; researchers have only comparatively recently reached the point of identifying specific differences that might be relevant, and then <a href="https://www.fightaging.org/a…
Source https://www.fightaging.org/archives/2025/10/introducing-naked-mole-rat-cgas-into-mice-and-flies-to-improve-dna-repair-and-treat-aging/
Naked mole-rats live as much as nine times longer than similarly sized rodent species, suffer little age-related decline of function until very late life, and there are next to no examples of individuals in captivity suffering from cancer. Researchers have spent more than twenty years investigating the biochemistry of this species, in search of the reasons for their longevity and resistance to cancer. As for other areas of the study of the comparative biology of aging, the hope is that some of these findings could form the basis for therapies to treat cancer and slow aging in humans. Whether this is the case remains to be seen; researchers have only comparatively recently reached the point of identifying specific differences that might be relevant, and then <a href="https://www.fightaging.org/a…
Source https://tinybuddha.com/blog/finding-balance-through-the-full-spectrum-of-emotion/
“As a solid rock is not shaken by the wind, the wise are not shaken by praise or blame.” ~The Dhammapada, Verse 81
Some moments lift you like moonlight. Others break you like a wave. I’ve lived through both—and I’ve come to believe that the way we move through these emotional thresholds defines who we become.
By thresholds, I mean the turning points in our lives—experiences so vivid, painful, or awe-filled that they pull us out of our usual routines and bring us face to face with something real. Some come in silence, others with sound and light, but they all leave a mark. And they ask something of us.
The Night the Frogs Were Singing</str…
Source https://tinybuddha.com/blog/finding-balance-through-the-full-spectrum-of-emotion/
“As a solid rock is not shaken by the wind, the wise are not shaken by praise or blame.” ~The Dhammapada, Verse 81
Some moments lift you like moonlight. Others break you like a wave. I’ve lived through both—and I’ve come to believe that the way we move through these emotional thresholds defines who we become.
By thresholds, I mean the turning points in our lives—experiences so vivid, painful, or awe-filled that they pull us out of our usual routines and bring us face to face with something real. Some come in silence, others with sound and light, but they all leave a mark. And they ask something of us.
The Night the Frogs Were Singing</str…
Source https://tinybuddha.com/blog/the-song-that-surprisingly-brought-me-back-to-life/
“Music was my refuge. I could crawl into the space between the notes and curl my back to loneliness.” ~Maya Angelou
I used to believe that healing and personal transformation required a lot of effort—writing page after page in a journal or getting up at the crack of dawn to carry out a morning routine, to name a couple.
When I moved through a phase of numbness—or the tunnel of darkness, as I now call it—it was frightening, and there seemed to be no end in sight. But one song found me at the right moment and changed everything.
In under five minutes, it achieved what all the tools and knowledge I had couldn’t: it made me feel something.
<p style="font-weig…
Source https://tinybuddha.com/blog/the-song-that-surprisingly-brought-me-back-to-life/
“Music was my refuge. I could crawl into the space between the notes and curl my back to loneliness.” ~Maya Angelou
I used to believe that healing and personal transformation required a lot of effort—writing page after page in a journal or getting up at the crack of dawn to carry out a morning routine, to name a couple.
When I moved through a phase of numbness—or the tunnel of darkness, as I now call it—it was frightening, and there seemed to be no end in sight. But one song found me at the right moment and changed everything.
In under five minutes, it achieved what all the tools and knowledge I had couldn’t: it made me feel something.
<p style="font-weig…
Source https://seniorplanet.org/articles-cartoonist-stan-mack/
Legendary cartoonist Stan Mack, best known for his nonfiction comic strip Stan Mack’s Real Life Funnies, talks about cartooning, humor, aging and caretaking.
The post Cartoonist Stan Mack Keeps the Adventure Going appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-cartoonist-stan-mack/
Legendary cartoonist Stan Mack, best known for his nonfiction comic strip Stan Mack’s Real Life Funnies, talks about cartooning, humor, aging and caretaking.
The post Cartoonist Stan Mack Keeps the Adventure Going appeared first on Senior Planet from AARP.
…
Source https://www.theminimalists.com/allergic/
The Minimalists discuss Joshua’s allergy to clutter.
What kind of clutter are you allergic to? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Help Me with My Kitchen Table Clutter! appeared first on The Minimalists.
…
Source https://www.theminimalists.com/allergic/
The Minimalists discuss Joshua’s allergy to clutter.
What kind of clutter are you allergic to? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Help Me with My Kitchen Table Clutter! appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/centenarian-natural-killer-cells-exhibit-aspects-of-a-relatively-youthful-phenotype/
A number of studies have suggested that people who survive to extreme old age exhibit better immune function throughout later life in comparison to peers who died at earlier ages. This analysis is an example of the type, and the data shows a natural killer cell population that exhibits signs of greater efficiency and more youthful activity. How and why long-lived individuals exhibit better immune function is a separate question. Studies of genetic variation in very large human data sets suggest that genetics plays a much smaller role in late life survival than the consequences of lifestyle choices (such as physical fitness) and environment…
Source https://www.fightaging.org/archives/2025/10/centenarian-natural-killer-cells-exhibit-aspects-of-a-relatively-youthful-phenotype/
A number of studies have suggested that people who survive to extreme old age exhibit better immune function throughout later life in comparison to peers who died at earlier ages. This analysis is an example of the type, and the data shows a natural killer cell population that exhibits signs of greater efficiency and more youthful activity. How and why long-lived individuals exhibit better immune function is a separate question. Studies of genetic variation in very large human data sets suggest that genetics plays a much smaller role in late life survival than the consequences of lifestyle choices (such as physical fitness) and environment…
Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/
Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…
Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/
Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…
Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/
Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…
Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/
Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…
Source https://www.fightaging.org/archives/2025/10/engineering-greater-export-of-amyloid-%CE%B2-through-the-blood-brain-barrier/
Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…
Source https://www.fightaging.org/archives/2025/10/engineering-greater-export-of-amyloid-%CE%B2-through-the-blood-brain-barrier/
Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…