Source https://www.fightaging.org/archives/2023/11/applying-proteomics-to-the-development-of-senolytic-therapies/
A cell can enter a senescent state in response to various forms of damage and stress, including the short telomeres that occur when reaching the Hayflick limit on cellular replication. A senescent cell ceases to replicate and secretes pro-inflammatory signals, attracting the attention of the immune system. Senescent cells help to suppress cancer by pointing the immune system to areas of potential risk in tissue, and are a part of the response to injury, …
Source https://www.fightaging.org/archives/2023/11/applying-proteomics-to-the-development-of-senolytic-therapies/
A cell can enter a senescent state in response to various forms of damage and stress, including the short telomeres that occur when reaching the Hayflick limit on cellular replication. A senescent cell ceases to replicate and secretes pro-inflammatory signals, attracting the attention of the immune system. Senescent cells help to suppress cancer by pointing the immune system to areas of potential risk in tissue, and are a part of the response to injury, …
Source https://seniorplanet.org/articles-volunteer-get-social/
Animals? Nature? What’s your pleasure? Use our guide to find the volunteer opportunity that feeds your passion while meeting new people.
The post Volunteer – and Get Social! appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-volunteer-get-social/
Animals? Nature? What’s your pleasure? Use our guide to find the volunteer opportunity that feeds your passion while meeting new people.
The post Volunteer – and Get Social! appeared first on Senior Planet from AARP.
…
Source https://www.theminimalists.com/p420/
In this public episode of The Minimalists Podcast, we speak with Leo Babauta from Zen Habits about bringing meaning to our everyday lives and getting back on track with minimalism. Watch all 2 hours of episode 420 on The Minimalists Private Podcast.
Subscribe
Apple · Spotify · Google · Soundcloud · MP3
Discussed in This Episode
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Source https://www.theminimalists.com/p420/
In this public episode of The Minimalists Podcast, we speak with Leo Babauta from Zen Habits about bringing meaning to our everyday lives and getting back on track with minimalism. Watch all 2 hours of episode 420 on The Minimalists Private Podcast.
Subscribe
Apple · Spotify · Google · Soundcloud · MP3
Discussed in This Episode
<div class="DraftEditor-paragraphElement" data-block="true" data-editor="252cq" data-offset-key="e5mge-…
Source https://tinybuddha.com/blog/always-exhausted-native-wisdom-to-restore-your-energy/
TRIGGER WARNING: This post references sexual assault and may be triggering to some people.
“Spirit carved by Nature
Here I am.
Slowly ascending
toward my own profundity.”
~Elicura Chihuailaf
That exhaustion you feel when your body is fighting something, the feeling of being completely drained to the point where you can barely move your body…. that’s how I felt when I was living with trauma.
Over the years it had piled up inside of me—the sexual assault I survived one night after I’d just turned twenty, the physical and emotional abuse that went on almost daily when I lived with my e…
Source https://tinybuddha.com/blog/always-exhausted-native-wisdom-to-restore-your-energy/
TRIGGER WARNING: This post references sexual assault and may be triggering to some people.
“Spirit carved by Nature
Here I am.
Slowly ascending
toward my own profundity.”
~Elicura Chihuailaf
That exhaustion you feel when your body is fighting something, the feeling of being completely drained to the point where you can barely move your body…. that’s how I felt when I was living with trauma.
Over the years it had piled up inside of me—the sexual assault I survived one night after I’d just turned twenty, the physical and emotional abuse that went on almost daily when I lived with my e…
Source https://www.fightaging.org/archives/2023/11/further-evidence-for-reduced-blood-pressure-to-lower-risk-of-dementia/
The raised blood pressure of hypertension causes a great deal of downstream damage. It is a way for low-level biochemical damage associated with aging to become actual physical damage to the body. Pressure damage can occur in delicate tissues throughout the body, and raised blood pressure increases the pace at which capillaries and other small vessels rupture. Further, increased blood pressure can accelerate the development of atherosclerosis, and also contributes to the pathological enlargement and weakenin…
Source https://www.fightaging.org/archives/2023/11/further-evidence-for-reduced-blood-pressure-to-lower-risk-of-dementia/
The raised blood pressure of hypertension causes a great deal of downstream damage. It is a way for low-level biochemical damage associated with aging to become actual physical damage to the body. Pressure damage can occur in delicate tissues throughout the body, and raised blood pressure increases the pace at which capillaries and other small vessels rupture. Further, increased blood pressure can accelerate the development of atherosclerosis, and also contributes to the pathological enlargement and weakenin…
Source https://www.fightaging.org/archives/2023/11/an-aging-clock-derived-from-images-of-the-lens-of-the-eye/
Recent years have made it clear that any sufficiently large set of data derived from biochemistry or physiology can be fed into a machine learning process to develop an weighted combination of measures that reflects biological age. These aging clocks have been derived from many forms of omics data, from frequently measured blood biomarkers, from various other combination of common measures of health. Interestingly, photography of the face and, separately, of retinal structure also provide enough data for the development of clocks. In today’s open access paper, researchers report on a clock developed from photography of the lens of th…
Source https://www.fightaging.org/archives/2023/11/an-aging-clock-derived-from-images-of-the-lens-of-the-eye/
Recent years have made it clear that any sufficiently large set of data derived from biochemistry or physiology can be fed into a machine learning process to develop an weighted combination of measures that reflects biological age. These aging clocks have been derived from many forms of omics data, from frequently measured blood biomarkers, from various other combination of common measures of health. Interestingly, photography of the face and, separately, of retinal structure also provide enough data for the development of clocks. In today’s open access paper, researchers report on a clock developed from photography of the lens of th…
Source https://www.fightaging.org/archives/2023/11/senescent-cells-in-the-human-brain/
Study of the biochemistry of the human brain is hindered by the difficulty of accessing tissue samples. Most work is conducted on post-mortem tissue rather than samples taken from a living brain (such as during surgery), and few research groups have the necessary connections to obtain these materials. Thus the development of brain organoids is important in this part of the medical research field, even given that most present organoid recipes result in a poor substitute for actual tissue. Here, researchers use post-mortem tissue and organoids to demonstrate that senescent cells are important in the aging of the brain, and in the effects of COVID-19. This is one of many data points to suggest that treatment with senolytics capable of passing the blood-brai…
Source https://www.fightaging.org/archives/2023/11/senescent-cells-in-the-human-brain/
Study of the biochemistry of the human brain is hindered by the difficulty of accessing tissue samples. Most work is conducted on post-mortem tissue rather than samples taken from a living brain (such as during surgery), and few research groups have the necessary connections to obtain these materials. Thus the development of brain organoids is important in this part of the medical research field, even given that most present organoid recipes result in a poor substitute for actual tissue. Here, researchers use post-mortem tissue and organoids to demonstrate that senescent cells are important in the aging of the brain, and in the effects of COVID-19. This is one of many data points to suggest that treatment with senolytics capable of passing the blood-brai…
Source https://www.fightaging.org/archives/2023/11/bioprinting-skin-with-hair-follicles/
In that part of the tissue engineering community concerned with trying to reproduce natural skin structure, as best as possible with present technology, bioprinting is currently largely used for research and development rather than directly in clinical application as a regenerative therapy. For example, skin models are used in the screening and testing of topical therapies, and greater fidelity with natural skin gives more relevant information. Skin is a complex structure, in which cells associated with sweat glands and hair follicles appear to be important in coordinating growth and healing. The work noted here is an example of the state of the art in bioprinted skin; it remains to be seen as to the timeline for widespread use in the clinic.
…
Source https://www.fightaging.org/archives/2023/11/bioprinting-skin-with-hair-follicles/
In that part of the tissue engineering community concerned with trying to reproduce natural skin structure, as best as possible with present technology, bioprinting is currently largely used for research and development rather than directly in clinical application as a regenerative therapy. For example, skin models are used in the screening and testing of topical therapies, and greater fidelity with natural skin gives more relevant information. Skin is a complex structure, in which cells associated with sweat glands and hair follicles appear to be important in coordinating growth and healing. The work noted here is an example of the state of the art in bioprinted skin; it remains to be seen as to the timeline for widespread use in the clinic.
…
Source https://www.fightaging.org/archives/2023/11/usp30-inhibition-stops-progression-of-parkinsons-disease-in-mice/
Parkinson’s disease arises from the spread of misfolded α-synuclein proteins in the nervous system. This produces a wide array of dysfunction, but the most vulnerable cell population to this particular form of neurodegenerative pathology are domaminergenic cells. Their loss provokes the most evident symptoms of the condition. As noted here, this vulnerability appears to have something to do with clearance of damaged mitochondria, and thus with mitochondrial function more generally. Researchers are investigating ways to improve the situation, such as this representative <a href="https://en.wikipedia.org/wiki/Small_molecule"…
Source https://www.fightaging.org/archives/2023/11/usp30-inhibition-stops-progression-of-parkinsons-disease-in-mice/
Parkinson’s disease arises from the spread of misfolded α-synuclein proteins in the nervous system. This produces a wide array of dysfunction, but the most vulnerable cell population to this particular form of neurodegenerative pathology are domaminergenic cells. Their loss provokes the most evident symptoms of the condition. As noted here, this vulnerability appears to have something to do with clearance of damaged mitochondria, and thus with mitochondrial function more generally. Researchers are investigating ways to improve the situation, such as this representative <a href="https://en.wikipedia.org/wiki/Small_molecule"…
Source https://www.fightaging.org/archives/2023/11/a-novel-mitophagy-inducing-compound/
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis would be on different approaches.
Today’s publicity materials are a good example of the way in which unbiased screening works. It tends to find ways to influence the well-known set of mechanisms related to the cal…
Source https://www.fightaging.org/archives/2023/11/a-novel-mitophagy-inducing-compound/
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis would be on different approaches.
Today’s publicity materials are a good example of the way in which unbiased screening works. It tends to find ways to influence the well-known set of mechanisms related to the cal…