Author: Tom

HAPLN2 Forms Aggregates to Provoke Microglial Inflammation in the Aging Brain

Source https://www.fightaging.org/archives/2025/08/hapln2-forms-aggregates-to-provoke-microglial-inflammation-in-the-aging-brain/

A small number of proteins in the body and brain are known to become misfolded or altered in ways that provoke the formation of extensive, harmful protein aggregates. Neurodegenerative conditions in particular are strongly linked to the aggregates of specific proteins, such as amyloid-β, tau, and α-synuclein. Researchers continue to discover new proteins that produce aggregates capable of contributing significantly to forms of age-related disease, however. That TDP-43 aggregates to cause a prominent form of dementia is a comparative…

Source https://www.fightaging.org/archives/2025/08/hapln2-forms-aggregates-to-provoke-microglial-inflammation-in-the-aging-brain/

A small number of proteins in the body and brain are known to become misfolded or altered in ways that provoke the formation of extensive, harmful protein aggregates. Neurodegenerative conditions in particular are strongly linked to the aggregates of specific proteins, such as amyloid-β, tau, and α-synuclein. Researchers continue to discover new proteins that produce aggregates capable of contributing significantly to forms of age-related disease, however. That TDP-43 aggregates to cause a prominent form of dementia is a comparative…

Cabozantinib is a Senotherapeutic that Slows Osteoporosis

Source https://www.fightaging.org/archives/2025/08/cabozantinib-is-a-senotherapeutic-that-slows-osteoporosis/

The development of cancer is strongly affected by the presence of senescent cells. Cellular senescence is a tool of cancer suppression in the earliest stages at which cancers emerge from cell damage, attempting to halt replication in damaged cells as well as call in the immune system via inflammatory signaling to destroy potentially cancerous cells. Senescent cells are also involved in wound healing and coordination of regeneration, however, and this capacity can be subverted by an established tumor to support its growth. Once a cancer is established, the accumulation of senescent cells in and around tumor tissue creates a more favorable environmen…

Source https://www.fightaging.org/archives/2025/08/cabozantinib-is-a-senotherapeutic-that-slows-osteoporosis/

The development of cancer is strongly affected by the presence of senescent cells. Cellular senescence is a tool of cancer suppression in the earliest stages at which cancers emerge from cell damage, attempting to halt replication in damaged cells as well as call in the immune system via inflammatory signaling to destroy potentially cancerous cells. Senescent cells are also involved in wound healing and coordination of regeneration, however, and this capacity can be subverted by an established tumor to support its growth. Once a cancer is established, the accumulation of senescent cells in and around tumor tissue creates a more favorable environmen…

FTL1 Inhibition in Neurons Slows Brain Aging in Mice

Source https://www.fightaging.org/archives/2025/08/ftl1-inhibition-in-neurons-slows-brain-aging-in-mice/

Changes in the expression of countless genes takes place with aging. Some of these changes are adaptive, attempts to resist the damaged environment or compensate for other impaired functions. Many are maladaptive and actively cause harm. Researchers here identify a specific maladaptive change in expression in neurons in the brains of aged mice, an increase in FTL1 that appears to produce a range of harm that contributes to loss of cognitive function.

Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cogn…

Source https://www.fightaging.org/archives/2025/08/ftl1-inhibition-in-neurons-slows-brain-aging-in-mice/

Changes in the expression of countless genes takes place with aging. Some of these changes are adaptive, attempts to resist the damaged environment or compensate for other impaired functions. Many are maladaptive and actively cause harm. Researchers here identify a specific maladaptive change in expression in neurons in the brains of aged mice, an increase in FTL1 that appears to produce a range of harm that contributes to loss of cognitive function.

Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cogn…

UCP4A Knockdown in Muscles Removes Protein Aggregates to Extend Life in Flies

Source https://www.fightaging.org/archives/2025/08/ucp4a-knockdown-in-muscles-removes-protein-aggregates-to-extend-life-in-flies/

Cellular metabolism is a complex web of connections. For any well known protein that regulates metabolism in ways relevant to aging that can be affected directly by various small molecules, gene therapies, or mutations, there are probably a score of other ways to indirectly affect its expression and activity. The mTOR pathway is well researched, as suppression of mTOR activity is a part of the response to low nutrient levels that adjusts cellular biochemistry in favor of conservation and increased maintenance, such as via an upregulation of autophagy…

Source https://www.fightaging.org/archives/2025/08/ucp4a-knockdown-in-muscles-removes-protein-aggregates-to-extend-life-in-flies/

Cellular metabolism is a complex web of connections. For any well known protein that regulates metabolism in ways relevant to aging that can be affected directly by various small molecules, gene therapies, or mutations, there are probably a score of other ways to indirectly affect its expression and activity. The mTOR pathway is well researched, as suppression of mTOR activity is a part of the response to low nutrient levels that adjusts cellular biochemistry in favor of conservation and increased maintenance, such as via an upregulation of autophagy…

Get Social…and Ditch the Mess

Source https://seniorplanet.org/articles-social-the-mess/

Decluttering your environment – the average US home has some 300,000 items – is an easy way to be more productive, calmer…and social.

The post Get Social…and Ditch the Mess appeared first on Senior Planet from AARP.

…

Source https://seniorplanet.org/articles-social-the-mess/

Decluttering your environment – the average US home has some 300,000 items – is an easy way to be more productive, calmer…and social.

The post Get Social…and Ditch the Mess appeared first on Senior Planet from AARP.

…

Application of Keratin Repairs Tooth Enamel

Source https://www.fightaging.org/archives/2025/08/application-of-keratin-repairs-tooth-enamel/

While modern dentistry offers a range of good-enough approaches to damaged teeth, regeneration of lost enamel remains a much desired capability. Here, researchers show that the application of keratin to damaged tooth enamel provokes the formation of an enamel-like replacement structure. This is quite interesting, and simple enough in implementation that it could emerge as a widespread option in the near future.

Scientists discovered that keratin, a protein found in hair, skin and wool, can repair tooth enamel and stop early stages of decay. Keratin forms a dense mineral layer that protects the tooth and seals off exposed nerve channels that cause sensitivity, offering both structural and symptomatic relief. The treatment could be delivered through a toothpaste for daily use or as a professionally applied gel, similar to nail varnish, for …

Source https://www.fightaging.org/archives/2025/08/application-of-keratin-repairs-tooth-enamel/

While modern dentistry offers a range of good-enough approaches to damaged teeth, regeneration of lost enamel remains a much desired capability. Here, researchers show that the application of keratin to damaged tooth enamel provokes the formation of an enamel-like replacement structure. This is quite interesting, and simple enough in implementation that it could emerge as a widespread option in the near future.

Scientists discovered that keratin, a protein found in hair, skin and wool, can repair tooth enamel and stop early stages of decay. Keratin forms a dense mineral layer that protects the tooth and seals off exposed nerve channels that cause sensitivity, offering both structural and symptomatic relief. The treatment could be delivered through a toothpaste for daily use or as a professionally applied gel, similar to nail varnish, for …

Reviewing What is Known of Mitochondrial Sirtuins in Aging

Source https://www.fightaging.org/archives/2025/08/reviewing-what-is-known-of-mitochondrial-sirtuins-in-aging/

The sirtuin family of proteins has attracted research interest for its involvement in mechanisms that may influence the pace of aging. While the overhyped work on the effects of sirtuin 1 on aging unraveled to produce no practical applications, sirtuin 3, sirtuin 4, and sirtuin 5 are localized in the mitochondria and there is a range of more convincing evidence to suggest that they can be manipulated to meaningfully adjust mitochondrial function in later life.

Sirtuins, colloquially termed “longevity proteins,” are central regulators in the intricate molecular netwo…

Source https://www.fightaging.org/archives/2025/08/reviewing-what-is-known-of-mitochondrial-sirtuins-in-aging/

The sirtuin family of proteins has attracted research interest for its involvement in mechanisms that may influence the pace of aging. While the overhyped work on the effects of sirtuin 1 on aging unraveled to produce no practical applications, sirtuin 3, sirtuin 4, and sirtuin 5 are localized in the mitochondria and there is a range of more convincing evidence to suggest that they can be manipulated to meaningfully adjust mitochondrial function in later life.

Sirtuins, colloquially termed “longevity proteins,” are central regulators in the intricate molecular netwo…

Fight Aging! Newsletter, August 25th 2025

Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-25th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

<a name="t…

Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-25th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

<a name="t…

Translate »