Senior Planet Book Club: While Justice Sleeps (Week 4)

Source https://seniorplanet.org/senior-planet-book-club-while-justice-sleeps-week-4/

We read chapters 29 – 42 this week. Let’s discuss!

The post Senior Planet Book Club: <em>While Justice Sleeps</em> (Week 4) appeared first on Senior Planet.

Source https://seniorplanet.org/senior-planet-book-club-while-justice-sleeps-week-4/

We read chapters 29 – 42 this week. Let’s discuss!

The post Senior Planet Book Club: <em>While Justice Sleeps</em> (Week 4) appeared first on Senior Planet.

Complicating the Contribution of Persistent Infection to Neurodegeneration and Alzheimer's Disease Risk

Source https://www.fightaging.org/archives/2021/08/complicating-the-contribution-of-persistent-infection-to-neurodegeneration-and-alzheimers-disease-risk/

Researchers have in recent years put forward contradictory evidence for and against a role for persistent infection, such as by herpesviruses, in neurodegeneration and the incidence of Alzheimer’s disease. The Alzheimer’s disease scientific community is in need of a good explanation as to why only some people with the known risk factors go on to develop the condition. That disease incidence in fact depends on the burden and duration of persistent infection would be a convenient answer, if true. It is often the case that contradictory evidence means that better segmentation of the population of interest is required. Along these lines, researchers here suggest that infection is more of a contributing cause to Alzheimer’s disease in people with the <a href="https://en.wikipedia.org/wiki/Apolipoprotein…

Source https://www.fightaging.org/archives/2021/08/complicating-the-contribution-of-persistent-infection-to-neurodegeneration-and-alzheimers-disease-risk/

Researchers have in recent years put forward contradictory evidence for and against a role for persistent infection, such as by herpesviruses, in neurodegeneration and the incidence of Alzheimer’s disease. The Alzheimer’s disease scientific community is in need of a good explanation as to why only some people with the known risk factors go on to develop the condition. That disease incidence in fact depends on the burden and duration of persistent infection would be a convenient answer, if true. It is often the case that contradictory evidence means that better segmentation of the population of interest is required. Along these lines, researchers here suggest that infection is more of a contributing cause to Alzheimer’s disease in people with the <a href="https://en.wikipedia.org/wiki/Apolipoprotein…

Honor buys Home Instead – a shakeup in the home care industry

Source https://www.ageinplacetech.com/blog/honor-buys-home-instead-shakeup-home-care-industry

Honor buys Home Instead: one of the newest acquires one of the oldest.  Honor, a recipient of $255 million in total investment (Series D in October, 2020), has pivoted here and there since its $20 million-fueled launch in 2015, always intent on disrupting the home care industry. For a while, many in the industry were skeptical. They vi…

Source https://www.ageinplacetech.com/blog/honor-buys-home-instead-shakeup-home-care-industry

Honor buys Home Instead: one of the newest acquires one of the oldest.  Honor, a recipient of $255 million in total investment (Series D in October, 2020), has pivoted here and there since its $20 million-fueled launch in 2015, always intent on disrupting the home care industry. For a while, many in the industry were skeptical. They vi…

Extracellular Vesicles from Young Mice Improve Health and Reduce Frailty in Old Mice

Source https://www.fightaging.org/archives/2021/08/extracellular-vesicles-from-young-mice-improve-health-and-reduce-frailty-in-old-mice/

Much of cell signaling is carried via extracellular vesicles, membrane-wrapped packages of molecules. Researchers are finding that delivery of extracellular vesicles harvested from stem cells may be a good replacement for first generation stem cell therapies, in which the transplanted cells produce benefits via signaling before dying. Extracellular vesicles are an easier, cheaper approach from a logistical point of view. Here, researchers show that only vesicles generated by stem cells from young mice are capable of producing an impact on frailty in old mice, an indication of the degree to which aging impacts cell signaling and function.

Source https://www.fightaging.org/archives/2021/08/extracellular-vesicles-from-young-mice-improve-health-and-reduce-frailty-in-old-mice/

Much of cell signaling is carried via extracellular vesicles, membrane-wrapped packages of molecules. Researchers are finding that delivery of extracellular vesicles harvested from stem cells may be a good replacement for first generation stem cell therapies, in which the transplanted cells produce benefits via signaling before dying. Extracellular vesicles are an easier, cheaper approach from a logistical point of view. Here, researchers show that only vesicles generated by stem cells from young mice are capable of producing an impact on frailty in old mice, an indication of the degree to which aging impacts cell signaling and function.

Battle of the Mom Butt: How to Get Your Booty Back After Pregnancy

Source https://greatist.com/health/mom-butt

Has pregnancy turned your bootylicious peach into a deflated balloon? If so, you’re not alone. The babymaking process can change the shape and feel of your tush. But(t) don’t worry! We’ve got the top tips to get your butt back on track. Here’s how to get rid of mom butt.

Mom butt 101

What’s a “mom butt”? Mom butt’s a term that generally refers to changes in the look and feel of your fanny during and after pregnancy.

Why does your butt get bigger after pregnancy? A larger, looser butt can be a natural result of weight gain, hormonal changes, and reduced physical activity.

How do you get rid of mom butt? A balanced, healthful diet paired with a consistent…

Source https://greatist.com/health/mom-butt

Has pregnancy turned your bootylicious peach into a deflated balloon? If so, you’re not alone. The babymaking process can change the shape and feel of your tush. But(t) don’t worry! We’ve got the top tips to get your butt back on track. Here’s how to get rid of mom butt.

Mom butt 101

What’s a “mom butt”? Mom butt’s a term that generally refers to changes in the look and feel of your fanny during and after pregnancy.

Why does your butt get bigger after pregnancy? A larger, looser butt can be a natural result of weight gain, hormonal changes, and reduced physical activity.

How do you get rid of mom butt? A balanced, healthful diet paired with a consistent…

How to Stop From Spinning Into Meltdown

Source https://zenhabits.net/meltdown/

By Leo Babauta

If you’re someone who tends spin out into a meltdown, rage, shutdown, or anxiety attack, things can be really difficult.

A small frustration or fear can be turned into something huge, and ruin your entire day.

If this is you, know that you’re not alone. This happens to a lot of people, in a variety of ways:

  • Getting frustrated with someone and then turning that into anger that can rage or simmer all day, putting you in a foul mood.
  • Feeling fear or hurt, you might get caught up in a mental narrative that causes you to have an anxiety attack or shut down, that might take you hours to recover from.
  • Feeling bad about something you did or failed to do, you might start spinning into feeling really bad about yourself, and drop into a state of discouragement about everything.

What can we do if this is happening? Let’s take a look at what’s …

Source https://zenhabits.net/meltdown/

By Leo Babauta

If you’re someone who tends spin out into a meltdown, rage, shutdown, or anxiety attack, things can be really difficult.

A small frustration or fear can be turned into something huge, and ruin your entire day.

If this is you, know that you’re not alone. This happens to a lot of people, in a variety of ways:

  • Getting frustrated with someone and then turning that into anger that can rage or simmer all day, putting you in a foul mood.
  • Feeling fear or hurt, you might get caught up in a mental narrative that causes you to have an anxiety attack or shut down, that might take you hours to recover from.
  • Feeling bad about something you did or failed to do, you might start spinning into feeling really bad about yourself, and drop into a state of discouragement about everything.

What can we do if this is happening? Let’s take a look at what’s …

An Interview with George Church on Gene Therapy and the Treatment of Aging as Medical Condition

Source https://www.fightaging.org/archives/2021/08/an-interview-with-george-church-on-gene-therapy-and-the-treatment-of-aging-as-medical-condition/

George Church is a noted geneticist, involved in a number of gene therapy projects that relate to aging in some way – though largely through manipulation of metabolism to slow aging rather than by directly attacking the root causes of aging. Gene therapy tends to lend itself to adjustment of cellular metabolism first and foremost, raising or lowering expression of regulatory proteins, but there are certainly ways in which it can be used to produce <a href="https://www.fightaging.org/archives/2016/11/predicting-the-order-of-arrival-of-the-first-rejuvenation-thera…

Source https://www.fightaging.org/archives/2021/08/an-interview-with-george-church-on-gene-therapy-and-the-treatment-of-aging-as-medical-condition/

George Church is a noted geneticist, involved in a number of gene therapy projects that relate to aging in some way – though largely through manipulation of metabolism to slow aging rather than by directly attacking the root causes of aging. Gene therapy tends to lend itself to adjustment of cellular metabolism first and foremost, raising or lowering expression of regulatory proteins, but there are certainly ways in which it can be used to produce <a href="https://www.fightaging.org/archives/2016/11/predicting-the-order-of-arrival-of-the-first-rejuvenation-thera…

Disruption of Naive T Cell Quiescence in Immune Aging

Source https://www.fightaging.org/archives/2021/08/disruption-of-naive-t-cell-quiescence-in-immune-aging/

This open access paper discusses a secondary issue in the aging of the adaptive immune system. Of primary concern is that the supply of new T cells diminishes over time, due to the atrophy of the thymus where such cells mature, as well as due to issues in the hematopoietic system of the bone marrow where such cells are produced. As noted here, a secondary concern is that the population of unspecialized naive T cells needed to respond effectively to novel threats begins to have issues maintaining itself in readiness. So not only is the supply of new naive T cells reduced to a tiny fraction of youthful levels, but the population present at any given time corrodes into ineffectiveness more rap…

Source https://www.fightaging.org/archives/2021/08/disruption-of-naive-t-cell-quiescence-in-immune-aging/

This open access paper discusses a secondary issue in the aging of the adaptive immune system. Of primary concern is that the supply of new T cells diminishes over time, due to the atrophy of the thymus where such cells mature, as well as due to issues in the hematopoietic system of the bone marrow where such cells are produced. As noted here, a secondary concern is that the population of unspecialized naive T cells needed to respond effectively to novel threats begins to have issues maintaining itself in readiness. So not only is the supply of new naive T cells reduced to a tiny fraction of youthful levels, but the population present at any given time corrodes into ineffectiveness more rap…

On the Mechanisms of Late-Life Depression

Source https://www.fightaging.org/archives/2021/08/on-the-mechanisms-of-late-life-depression/

Major depressive disorder, more commonly known as depression, is all too prevalent a part of the human condition. Like many aspects of brain function, a great many layered mechanisms are investigated and debated by the research community, while still being poorly understood as a whole. Pharmaceutical treatments for depression are actually quite good for those people that they work for, but finding the right treatment can be a haphazard, experimental journey of years and different approaches for those who suffer. We might suspect that these treatments are essentially compensatory in nature, touching on mechanisms (such as serotonin levels) that are somewhat downstream from root causes.

That regular exercise reliably helps with depression is evidence for both inflammation and <a href="https:…

Source https://www.fightaging.org/archives/2021/08/on-the-mechanisms-of-late-life-depression/

Major depressive disorder, more commonly known as depression, is all too prevalent a part of the human condition. Like many aspects of brain function, a great many layered mechanisms are investigated and debated by the research community, while still being poorly understood as a whole. Pharmaceutical treatments for depression are actually quite good for those people that they work for, but finding the right treatment can be a haphazard, experimental journey of years and different approaches for those who suffer. We might suspect that these treatments are essentially compensatory in nature, touching on mechanisms (such as serotonin levels) that are somewhat downstream from root causes.

That regular exercise reliably helps with depression is evidence for both inflammation and <a href="https:…

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