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Source https://www.fightaging.org/archives/2025/05/the-aged-blood-brain-barrier-is-more-vulnerable-to-disruption-by-hypoxia/

The blood-brain barrier consists of specialized cells that line blood vessels passing through the brain. These cells collectively permit only certain molecules to pass to and from the brain, maintaining the distinct biochemistry and cell populations of the central nervous system versus the rest of the body. Where the blood-brain barrier leaks, the result is inflammation and dysfunction in brain tissue as, a reaction to the presence of unexpected and unwanted molecules and cells. Unfortunately the blood-brain barrier declines and malfunctions with age, as is the case for all complex biological systems. This is likely an important contribution to the development of <a href="https://en.wikipedia.org/wiki/Neurodegener…

Source https://www.fightaging.org/archives/2025/05/fecal-microbiota-transplant-from-young-rats-to-old-rats-improves-memory/

The composition of the gut microbiome has been shown to change with age, undergoing a loss of beneficial microbes in favor of inflammatory microbes that contribute to the chronic inflammation of aging and onset and progression of age-related conditions. Researchers have comprehensively demonstrated in animal models that introducing a young microbiome into an old animal via fecal microbiota transplantation produces a lasting rejuvenation of the gut microbiome and corresponding improvements in meas…

Source https://tinybuddha.com/blog/feeling-stuck-anxious-or-lost-choose-your-free-guide/

If you’ve felt stuck lately, you’re not alone.

Since I launched the (very delayed) ​Best You, Best Life bundle​ on Monday, I’ve heard from so many people who are going through a lot right now—emotionally, mentally, and energetically.

Maybe you’re stuck in survival mode—going through the motions, n…

Source https://www.fightaging.org/archives/2025/05/another-mutation-causing-a-need-for-little-sleep/

It seems likely that the next century will see the engineering of new humans to have genetic alterations that have been identified as wholly beneficial. It is a lot easier to edit the genomes in an embryo than it is to adjust all of the cells in an adult in the same way, due to the issues of delivery of suitable genetic medicine to all cells in all tissues. One interesting class of beneficial gene variants are those associated with what is known as natural short sleep, a phenomenon in which a rare few human lineages need very little sleep, as little as a few hours a night. More time spent awake in a lifetime is somewhat analogous to living for longer. So far ADRB1 variants and <a href="https://www.fightaging.org/archives/2…

Source https://www.fightaging.org/archives/2025/05/stem-cell-and-extracellular-vesicle-therapies-as-treatments-for-aging/

Stem cell therapies have expanded in use over the last 30 years, and are now widespread. Substituting extracellular vesicles for the stem cells is a more recent innovation, but also now widely used in the medical tourism industry. These treatments have shown effects on aging and longevity in animal studies, but we have no idea whether this is the case in humans, and we are in no danger of finding out any time soon. Even short clinical trials are expensive, while trials large enough and long enough to assess effects on life span are prohibitively expensive. There is as yet no generally accepted and trusted measure of biological age one might apply to patients before and after a treatment. The existing <a href="https://doi.org/10.1002/…

Source https://seniorplanet.org/articles-bonnetta-adeeb-seeds/

Bonnetta Adeeb, a retired history teacher, founded the Ujamaa Cooperative Farming Alliance to help communities reconnect with their agricultural heritage- one seed at a time.

The post Bonnetta Adeeb Sows Seeds of Resistance appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/05/nucleoside-reverse-transcriptase-inhibitors-may-slow-the-development-of-alzheimers-disease/

Nucleoside reverse transcriptase inhibitors (NTRIs) were developed to treat HIV infection, interfering in the ability of the virus to replicate. Researchers here present epidemiological evidence for this class of drug to slow the onset of Alzheimer’s disease. The researchers focus on reduced inflammation as a driving mechanism, but it seems plausible that this outcome occurs because NTRI’s interfere in harmful transposable element activities. Transposable elements such as retrotransposons are largely the genetic remnants…

Source https://www.fightaging.org/archives/2025/05/even-small-amounts-of-high-intensity-exercise-slow-brain-aging/

The value of lower levels of physical activity has been one of the major themes of the past twenty years of research into the effects of exercise on long-term health. The advent of low-cost wearable accelerometer devices has enabled researchers to rigorously quantify differences for lesser amounts of physical activity, in order to get a much better look at the lower end of the dose-response curve for exercise. That leads to studies such as the one noted here, in which researchers assess the impact of small amounts of high intensity exercise on brain aging.

Endurance training and good fitness can reduce the risk of dementia and promote healthy brain aging. Even small amounts of physical activity may be enough to protect the aging brain, res…