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Assessing Gene Therapy to Upregulate Three Longevity-Associated Genes in Mice

Source https://www.fightaging.org/archives/2019/11/assessing-gene-therapy-to-upregulate-three-longevity-associated-genes-in-mice/

Today’s open access research materials report on results obtained in mice using gene therapy to upregulates protein production of several longevity-associated genes. As expected from prior research into these genes and their influence on the operation of metabolism, health is improved in mouse models of age-related disease. As might also be expected based on past results, some combinations are not effective for reasons that remain to be explored: metabolism is complicated, and pulling on levers and turning dials rarely does exactly what was expected.

Evolution does not produce optimal organisms, as seen from the perspective of the individual. This is well illustrated in mice, where any number of single gene alterations, even just dialing up or down the amount of protein produced over time, leads to be…

Source https://www.fightaging.org/archives/2019/11/assessing-gene-therapy-to-upregulate-three-longevity-associated-genes-in-mice/

Today’s open access research materials report on results obtained in mice using gene therapy to upregulates protein production of several longevity-associated genes. As expected from prior research into these genes and their influence on the operation of metabolism, health is improved in mouse models of age-related disease. As might also be expected based on past results, some combinations are not effective for reasons that remain to be explored: metabolism is complicated, and pulling on levers and turning dials rarely does exactly what was expected.

Evolution does not produce optimal organisms, as seen from the perspective of the individual. This is well illustrated in mice, where any number of single gene alterations, even just dialing up or down the amount of protein produced over time, leads to be…

10 Niyamas: Personal Observances to Deepen Your Yoga Practice

Source https://www.sonima.com/yoga/yoga-articles/niyamas/

In the Yoga Sutras, Patanjali defines the eight limbs of Aṣṭāṅga yoga that help one reach the “state” of yoga. The second limb is niyama, which can be translated to mean “personal observances.” Like the yamas, the practice of the niyamas is a way to help bring the mind into a state of balance for the purpose of yoga. While the yamas relate more to our interactions with the external world, the focus of the niyamas is more internal. The practices support connecting to the jivātman (soul) and Paramātman (supreme soul).

The Hatha Yoga Pradipika and Yoga Yajñavalkya list 10 niyamas, which are also mentioned by Krishnamacharya in his Yoga Makaranda. Below are brief descriptions of these 10 niyamas.

1. Tapas is the effort that is required t…

Source https://www.sonima.com/yoga/yoga-articles/niyamas/

In the Yoga Sutras, Patanjali defines the eight limbs of Aṣṭāṅga yoga that help one reach the “state” of yoga. The second limb is niyama, which can be translated to mean “personal observances.” Like the yamas, the practice of the niyamas is a way to help bring the mind into a state of balance for the purpose of yoga. While the yamas relate more to our interactions with the external world, the focus of the niyamas is more internal. The practices support connecting to the jivātman (soul) and Paramātman (supreme soul).

The Hatha Yoga Pradipika and Yoga Yajñavalkya list 10 niyamas, which are also mentioned by Krishnamacharya in his Yoga Makaranda. Below are brief descriptions of these 10 niyamas.

1. Tapas is the effort that is required t…

Broccoli: the vegetable v. its antioxidant sulforaphane

Source https://www.foodpolitics.com/2019/11/broccoli-the-vegetable-v-its-antioxidant-sulforaphane/

Thomas Björkman, Professor of Vegetable Crop Physiology at Cornell University wrote to ask me what I thought about this new review article about the benefits of sulforaphane, an antioxidant in broccoli.  He explains:

It is a review by Jed Fahey et al on the value of sulphoraphane in broccoli. Go right to section 4, where they discuss the ins and outs of making dietary or clinical recommendations, and getting relevant research to inform those recommendations. They are pretty thoughtful and detailed about the issues so it seems like a good vehicle for discussion on your blog and elsewhere.

They particularly note, “the clinical studies that we have performed with broccoli and broccoli sprouts have already strained the academic system to the breaking point. The food industry needs to step up.”  That idea pushes against a couple of the arguments I see you making…I just figure that access to bet…

Source https://www.foodpolitics.com/2019/11/broccoli-the-vegetable-v-its-antioxidant-sulforaphane/

Thomas Björkman, Professor of Vegetable Crop Physiology at Cornell University wrote to ask me what I thought about this new review article about the benefits of sulforaphane, an antioxidant in broccoli.  He explains:

It is a review by Jed Fahey et al on the value of sulphoraphane in broccoli. Go right to section 4, where they discuss the ins and outs of making dietary or clinical recommendations, and getting relevant research to inform those recommendations. They are pretty thoughtful and detailed about the issues so it seems like a good vehicle for discussion on your blog and elsewhere.

They particularly note, “the clinical studies that we have performed with broccoli and broccoli sprouts have already strained the academic system to the breaking point. The food industry needs to step up.”  That idea pushes against a couple of the arguments I see you making…I just figure that access to bet…

A new smartphone – life is too short to keep up with such ‘innovation’

Source https://www.ageinplacetech.com/blog/new-smartphone-life-too-short-keep-such-innovation

How much time do we spend setting up our ‘smart’ phones?  Every few years, I change phones. In the past, Android-to-Android, I wasted at least a full day customizing all the ‘improved’ features the way they were on the previous phone, setting up home screens, eliminating bloatware, and downloading apps that did not properly convert.  This time, it took me most of 2 weekend days to set up an iPhone to join family photo sharing. The access to photos – that was one of the good parts. Otherwise, it was maddening and sent me out to forums again and again.  I learned about the also-constant <a href="https://www.forbes.com/sites/davidphelan/2019/09/30/apple-ios-1312-now-live…

Source https://www.ageinplacetech.com/blog/new-smartphone-life-too-short-keep-such-innovation

How much time do we spend setting up our ‘smart’ phones?  Every few years, I change phones. In the past, Android-to-Android, I wasted at least a full day customizing all the ‘improved’ features the way they were on the previous phone, setting up home screens, eliminating bloatware, and downloading apps that did not properly convert.  This time, it took me most of 2 weekend days to set up an iPhone to join family photo sharing. The access to photos – that was one of the good parts. Otherwise, it was maddening and sent me out to forums again and again.  I learned about the also-constant <a href="https://www.forbes.com/sites/davidphelan/2019/09/30/apple-ios-1312-now-live…

The Launch of Sea Change 2.0 (and November’s Declutter Challenge)

Source http://zenhabits.net/sea-change-2/

By Leo Babauta

For the last few months, my team & I have been working on a new version of my Sea Change Program for changing habits and transforming your life… we’ve been internally calling it “Sea Change 2.0”.

Well, I’m excited to let you know that we just launched it!

It’s not only a much more beautiful website, it’s designed to be easier to find key information, it has curated, redesigned challenges, and much more. We think the program is great.

You can check it out here:

Sea Change 2.0 – Our Work of Love<…

Source http://zenhabits.net/sea-change-2/

By Leo Babauta

For the last few months, my team & I have been working on a new version of my Sea Change Program for changing habits and transforming your life… we’ve been internally calling it “Sea Change 2.0”.

Well, I’m excited to let you know that we just launched it!

It’s not only a much more beautiful website, it’s designed to be easier to find key information, it has curated, redesigned challenges, and much more. We think the program is great.

You can check it out here:

Sea Change 2.0 – Our Work of Love<…

Sex Differences in Stroke

Source: https://womensbrainhealth.org/better-thinking/sex-differences-in-stroke

by Women’s Brain Health Initiative: Stroke is a significant public health concern, and is a leading cause of death and disability worldwide. According to the Global Burden of Diseases, Injuries and Risk Factors Study 2016 (GBD 2016), there were 13.7……

Source: https://womensbrainhealth.org/better-thinking/sex-differences-in-stroke

by Women’s Brain Health Initiative: Stroke is a significant public health concern, and is a leading cause of death and disability worldwide. According to the Global Burden of Diseases, Injuries and Risk Factors Study 2016 (GBD 2016), there were 13.7……

McLaren and MindMaze race to the future

Source: https://sharpbrains.com/blog/2019/11/05/mclaren-and-mindmaze-race-to-the-future/

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F1’s McLaren Racing Extends Neurotechnology Partnership With MindMaze (SportTechie):

“Formula 1 team McLaren Racing has signed a multi-year partnership with Swiss neurotechnology firm MindMaze to continue testing neurosensing technology on its drivers.

MindMaze’s combination of virtual reality, motion capture and EEG brain scans has previously been used to assist stroke patients with recovery, and the company is also trying to develop a computer chip that can mimic the way the brain processes information. The company raised a $100 million funding round in 2016.

McLaren originally partnered with the compa…

Source: https://sharpbrains.com/blog/2019/11/05/mclaren-and-mindmaze-race-to-the-future/

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F1’s McLaren Racing Extends Neurotechnology Partnership With MindMaze (SportTechie):

“Formula 1 team McLaren Racing has signed a multi-year partnership with Swiss neurotechnology firm MindMaze to continue testing neurosensing technology on its drivers.

MindMaze’s combination of virtual reality, motion capture and EEG brain scans has previously been used to assist stroke patients with recovery, and the company is also trying to develop a computer chip that can mimic the way the brain processes information. The company raised a $100 million funding round in 2016.

McLaren originally partnered with the compa…

Podcast 205 | Career Advice

Source https://www.theminimalists.com/p205/

By Joshua Fields Millburn & Ryan Nicodemus ·

In this episode of The Minimalists Podcast, Joshua and Ryan discuss career advice, pursuing your passion, mentors, and the stepping stones to success with author and radio perso…

Source https://www.theminimalists.com/p205/

By Joshua Fields Millburn & Ryan Nicodemus ·

In this episode of The Minimalists Podcast, Joshua and Ryan discuss career advice, pursuing your passion, mentors, and the stepping stones to success with author and radio perso…

Get Together for Medical Marijuana

Source https://changingaging.org/culture-change/get-together-for-medical-marijuana/

While use of medical marijuana is gaining widespread acceptance for aches and pains, even among older adults, there’s something else the herb offers that may be its most important benefit. A reason to gather, to socialize — and help overcome the health hazards of loneliness, isolation and despair.

The post Get Together for Medical Marijuana appeared first on ChangingAging.

Source https://changingaging.org/culture-change/get-together-for-medical-marijuana/

While use of medical marijuana is gaining widespread acceptance for aches and pains, even among older adults, there’s something else the herb offers that may be its most important benefit. A reason to gather, to socialize — and help overcome the health hazards of loneliness, isolation and despair.

The post Get Together for Medical Marijuana appeared first on ChangingAging.

Do You Accept Your Partner’s Attempts to Repair?

Source http://feedproxy.google.com/~r/tinybuddha/~3/-4Kb-zhXT8U/

“I am not fully healed, I am not fully wise, I am still on my way. What matters is that I am moving forward.” ~Yung Pueblo

According to Dr. John Gottman, PhD, successful repair attempts are a “happy couple’s secret weapon.”

An attempt to repair is when our partner makes a mistake and then makes an attempt to fix it in their own way.

Their attempt may look very different than what we may want, and we may be tempted to react negatively, but we have a choice to catch ourselves and consciously choose a different response.

That’s part of our work in creating a loving partnership, releasing and surrendering the need to control. Allowing our partner to love and express love in their own way instead of demanding it our way only. Being ope…

Source http://feedproxy.google.com/~r/tinybuddha/~3/-4Kb-zhXT8U/

“I am not fully healed, I am not fully wise, I am still on my way. What matters is that I am moving forward.” ~Yung Pueblo

According to Dr. John Gottman, PhD, successful repair attempts are a “happy couple’s secret weapon.”

An attempt to repair is when our partner makes a mistake and then makes an attempt to fix it in their own way.

Their attempt may look very different than what we may want, and we may be tempted to react negatively, but we have a choice to catch ourselves and consciously choose a different response.

That’s part of our work in creating a loving partnership, releasing and surrendering the need to control. Allowing our partner to love and express love in their own way instead of demanding it our way only. Being ope…

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