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Fish Oil, Vitamin D No Help for Heart Risk, Cancer

Source: https://www.webmd.com/heart/news/20181110/fish-oil-vitamin-d-no-help-for-heart-risk-cancer?src=RSS_PUBLIC

fish oil

And new study finds no reason to get routine vitamin D tests, researchers say.

Source: https://www.webmd.com/heart/news/20181110/fish-oil-vitamin-d-no-help-for-heart-risk-cancer?src=RSS_PUBLIC

fish oil

And new study finds no reason to get routine vitamin D tests, researchers say.

RBC PRESENTS ENGAGING MILLENNIAL MINDS – PEACE OF MIND

Source: https://womensbrainhealth.org/better-thinking/rbc-presents-engaging-millennial-minds-peace-of-mind

by Women’s Brain Health Initiative: On Thursday November 22, join Women’s Brain Health Initiative’s Young Person’s Cabinet for the first event in Series 3 of Engaging Millennial Minds // Peace of Mind. Statistics show that millennials may be the most……

Source: https://womensbrainhealth.org/better-thinking/rbc-presents-engaging-millennial-minds-peace-of-mind

by Women’s Brain Health Initiative: On Thursday November 22, join Women’s Brain Health Initiative’s Young Person’s Cabinet for the first event in Series 3 of Engaging Millennial Minds // Peace of Mind. Statistics show that millennials may be the most……

Diabetes Drug Might Also Ease Heart Failure Risks

Source: https://www.webmd.com/heart-disease/news/20181110/diabetes-drug-might-also-ease-heart-failure-risks?src=RSS_PUBLIC

The new study included more than 17,000 type 2 diabetes patients aged 40 and older. Nearly 7,000 had heart disease and more than 10,000 had numerous risk factors for heart disease, Wiviott’s group said.

Source: https://www.webmd.com/heart-disease/news/20181110/diabetes-drug-might-also-ease-heart-failure-risks?src=RSS_PUBLIC

The new study included more than 17,000 type 2 diabetes patients aged 40 and older. Nearly 7,000 had heart disease and more than 10,000 had numerous risk factors for heart disease, Wiviott’s group said.

Need a favor Post-Op?

Source https://seniorplanet.org/need-a-favor-post-op/

Whether you need a colonoscopy, an eye operation, a hip or a knee replacement, or back surgery, there’s usually one common denominator: you need a ride home, because the anesthesia has to wear off. And you may also need some at-home help to recover. If you’re married or co-habitating, your partner typically gets the chauffeuring […]

Source https://seniorplanet.org/need-a-favor-post-op/

Whether you need a colonoscopy, an eye operation, a hip or a knee replacement, or back surgery, there’s usually one common denominator: you need a ride home, because the anesthesia has to wear off. And you may also need some at-home help to recover. If you’re married or co-habitating, your partner typically gets the chauffeuring […]

TBH Toolkits Featured in LeadingAge Recap by Eleanor Barbera

Source: https://totalbrainhealth.com/tbh-toolkits-featured-in-leadingage-recap-by-eleanor-barbera/

Eleanor Feldman Barbera, Ph.D., author of The Savvy Resident’s Guide, recently attended LeadingAge and wrote a blog for McKnights Long-Term Care News about her experience in which she mentioned our TBH Toolkits!

“Psychologist Cynthia Green, Ph.D., described the clinical and practical success of group brain training at her Total Brain Health booth, and I was excited to find that the ECRI Institute has conducted a “deep dive” into “Meeting Patients’ Behavioral Health Needs in Acute Care.” Among other things, it analyzes the business case …

Source: https://totalbrainhealth.com/tbh-toolkits-featured-in-leadingage-recap-by-eleanor-barbera/

Eleanor Feldman Barbera, Ph.D., author of The Savvy Resident’s Guide, recently attended LeadingAge and wrote a blog for McKnights Long-Term Care News about her experience in which she mentioned our TBH Toolkits!

“Psychologist Cynthia Green, Ph.D., described the clinical and practical success of group brain training at her Total Brain Health booth, and I was excited to find that the ECRI Institute has conducted a “deep dive” into “Meeting Patients’ Behavioral Health Needs in Acute Care.” Among other things, it analyzes the business case …

Ten best cities for Older Singles

Source https://seniorplanet.org/ten-best-cities-for-older-singles/

It’s never too late. Love can be found at any age. Some people prefer to connect with potential dates through online dating sites, while others still want to meet the “old-fashioned” way, in person.  But did you know that where you live could increase your odds of meeting someone? As first reported in an article […]

Source https://seniorplanet.org/ten-best-cities-for-older-singles/

It’s never too late. Love can be found at any age. Some people prefer to connect with potential dates through online dating sites, while others still want to meet the “old-fashioned” way, in person.  But did you know that where you live could increase your odds of meeting someone? As first reported in an article […]

Pregnancy sculpts women’s brains in preparation for motherhood

Source: http://yourbrainhealth.com.au/pregnancy-sculpts-womens-brains-in-preparation-for-motherhood/

Motherhood changes everything

Little did I know before I had my boys how completely and utterly being their mother would change EVERYTHING.

Having children threw the pieces of my life up in the air. The pieces settled again, but my body, outlook on life, sense of self and emotions have never been quite the same. Not only did I birth two beautiful boys into the world, I birthed a new identity.

Yes, I realise it is the ultimate cliché, but motherhood changes everything. It recalibrates our life course and realigns our lives.

My experience is not unique. For those of us who become mothers, is one of the most fundamental transformations we go through as women. And for many of us, parenthood brings with it powerful identity changes and conflicting emotions…

Source: http://yourbrainhealth.com.au/pregnancy-sculpts-womens-brains-in-preparation-for-motherhood/

Motherhood changes everything

Little did I know before I had my boys how completely and utterly being their mother would change EVERYTHING.

Having children threw the pieces of my life up in the air. The pieces settled again, but my body, outlook on life, sense of self and emotions have never been quite the same. Not only did I birth two beautiful boys into the world, I birthed a new identity.

Yes, I realise it is the ultimate cliché, but motherhood changes everything. It recalibrates our life course and realigns our lives.

My experience is not unique. For those of us who become mothers, is one of the most fundamental transformations we go through as women. And for many of us, parenthood brings with it powerful identity changes and conflicting emotions…

February 26–28th: Save the Date for the 2019 SharpBrains Virtual Summit and help shape the Future of Brain Health

Source: https://sharpbrains.com/blog/2018/11/09/february-26-28th-save-the-date-for-the-2019-sharpbrains-virtual-summit-and-help-shape-the-future-of-brain-health/

?

Imagine a free annual brain check-up — who should take it, and how could it help prevent/ delay/ treat cognitive decline and Alzheimer’s Disease?

Imagine your smartphone can detect early signs of depression or Parkinson’s Disease — would you like to know? Who else should know … or not know?

Imagine a videogame cleared by the FDA to treat ADHD or substance abuse — how will doctors prescribe it, patients access it, and insurers pay for it?

Imagine being responsible for the health & wellness of 100,000 people — how will you help them navigate interventions such as breathing/ exercise/ meditation/ apps/ biofeedback/ tDCS to regulate stress?

I…

Source: https://sharpbrains.com/blog/2018/11/09/february-26-28th-save-the-date-for-the-2019-sharpbrains-virtual-summit-and-help-shape-the-future-of-brain-health/

?

Imagine a free annual brain check-up — who should take it, and how could it help prevent/ delay/ treat cognitive decline and Alzheimer’s Disease?

Imagine your smartphone can detect early signs of depression or Parkinson’s Disease — would you like to know? Who else should know … or not know?

Imagine a videogame cleared by the FDA to treat ADHD or substance abuse — how will doctors prescribe it, patients access it, and insurers pay for it?

Imagine being responsible for the health & wellness of 100,000 people — how will you help them navigate interventions such as breathing/ exercise/ meditation/ apps/ biofeedback/ tDCS to regulate stress?

I…

A Mechanism by Which Hypertension Accelerates Atherosclerosis

Source https://www.fightaging.org/archives/2018/11/a-mechanism-by-which-hypertension-accelerates-atherosclerosis/

The raised blood pressure of old age is known as hypertension, and it is predominantly caused by dysfunction in blood vessel walls: cross-links, calcification, and loss of elastin cause reduced elasticity, while smooth muscle cells lose their capacity to act for a variety of other reasons. When blood vessels can no longer correctly react to circumstances by contracting and dilating to an appropriate degree, then the whole system of pressure control is thrown off, and higher blood pressure is the result.

Atherosclerosis, on the other hand, is the progressive formation of fatty plaques in blood vessel walls. This narrows and weakens blood vessels. Atherosclerosis interacts with hypertension in the obvious way: weakened blood vessels and fragile plaques are more likely to suffer catastrophic structural failure in a high pressure environment, leading to a fatal stroke or heart attack. Just considering this interaction, it is clear that hypertension raises the risk of death and shortens life expectancy. This isn’t the only interaction, however, just the most direct one. In addition, hypertension accelerates the growth of atherosclerotic plaques, and the reasons for this are not fully understood.

In the research materials noted here, the authors report on an association between a particular subset of cases of hypertension and the pace at which immune cells known as monocytes arrive at atherosclerotic plaques in order to try to clean them up. Once embedded into the blood vessel wall, monocytes transform into macrophages. Plaques grow because these macrophages become overwhelmed by oxidized lipids, fail in their task of rescue, and die. Worse, many become inflammatory, senescent foam cells that linger to secrete signals that call in more of their peers. The bulk of a plaque is cell debris, and atherosclerosis is really a form of runaway garbage catastrophe. Once things get to the tipping point, the end is inevitable. In some cases, hypertension moves that tipping point in an undesirable direction by causing the production of more monocytes.

Neural driven blood pressure accelerates atherosclerotic cardiovascular disease through over production of monocytes

Atherosclerotic cardiovascular disease is a build-up of cholesterol plaque in the walls of arteries, causing obstruction of blood flow. Scientists have found that high blood pressure caused by specific signalling from the brain promotes heart disease by altering stem cells within the bone marrow. The results demonstrate how an overactive sympathetic nervous system that causes elevated blood pressure can instruct bone marrow stem cells to produce more white blood cells that clog up blood vessels.

“We now know that changes in the immune system contribute significantly to heart disease. We aimed to determine how the sympathetic nervous system through the brain directly promotes atherosclerosis in the setting of hypertension. We have discovered that this form of high blood pressure, often associated with stress, causes changes within the bone marrow leading to increased white blood cells circulating though our vessels. This is significant as the general view of hypertension is that it is mainly a disease of the blood vessels, which means other heart damaging events are missed.” The team is now exploring the specific molecules involved, which may shed light as to why some current therapies are ineffective.

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated blood pressure. We aimed to determine how the sympathetic nervous system directly promotes atherosclerosis in the setting of hypertension. We used a mouse model of sympathetic nervous system-driven hypertension on the atherosclerotic-prone apolipoprotein E deficient background. When mice were placed on a western type diet for 16 weeks we showed the evolution of unstable atherosclerotic lesions. Fortuitously, the changes in lesion composition were independent of endothelial dysfunction, allowing for the discovery of alternative mechanisms.

With the use of flow cytometry and bone marrow imaging, we found that sympathetic activation caused deterioration of the hematopoietic stem and progenitor cell niche in the bone marrow, promoting the liberation of these cells into the circulation and extramedullary hematopoiesis in the spleen. Specifically, sympathetic activation reduced the abundance of key hematopoietic stem and progenitor cell niche cells, sinusoidal endothelial cells, and osteoblasts. Additionally, sympathetic bone marrow activity prompted neutrophils to secrete proteases to cleave the hematopoietic stem and progenitor cell surface receptor CXCR4. All these effects could be reversed using the β-blocker propranolol during the feeding period. These findings suggest that elevated blood pressure driven by the sympathetic nervous system can influence mechanisms that modulate the hematopoietic system to promote atherosclerosis and contribute to cardiovascular events.

Source https://www.fightaging.org/archives/2018/11/a-mechanism-by-which-hypertension-accelerates-atherosclerosis/

The raised blood pressure of old age is known as hypertension, and it is predominantly caused by dysfunction in blood vessel walls: cross-links, calcification, and loss of elastin cause reduced elasticity, while smooth muscle cells lose their capacity to act for a variety of other reasons. When blood vessels can no longer correctly react to circumstances by contracting and dilating to an appropriate degree, then the whole system of pressure control is thrown off, and higher blood pressure is the result.

Atherosclerosis, on the other hand, is the progressive formation of fatty plaques in blood vessel walls. This narrows and weakens blood vessels. Atherosclerosis interacts with hypertension in the obvious way: weakened blood vessels and fragile plaques are more likely to suffer catastrophic structural failure in a high pressure environment, leading to a fatal stroke or heart attack. Just considering this interaction, it is clear that hypertension raises the risk of death and shortens life expectancy. This isn’t the only interaction, however, just the most direct one. In addition, hypertension accelerates the growth of atherosclerotic plaques, and the reasons for this are not fully understood.

In the research materials noted here, the authors report on an association between a particular subset of cases of hypertension and the pace at which immune cells known as monocytes arrive at atherosclerotic plaques in order to try to clean them up. Once embedded into the blood vessel wall, monocytes transform into macrophages. Plaques grow because these macrophages become overwhelmed by oxidized lipids, fail in their task of rescue, and die. Worse, many become inflammatory, senescent foam cells that linger to secrete signals that call in more of their peers. The bulk of a plaque is cell debris, and atherosclerosis is really a form of runaway garbage catastrophe. Once things get to the tipping point, the end is inevitable. In some cases, hypertension moves that tipping point in an undesirable direction by causing the production of more monocytes.

Neural driven blood pressure accelerates atherosclerotic cardiovascular disease through over production of monocytes

Atherosclerotic cardiovascular disease is a build-up of cholesterol plaque in the walls of arteries, causing obstruction of blood flow. Scientists have found that high blood pressure caused by specific signalling from the brain promotes heart disease by altering stem cells within the bone marrow. The results demonstrate how an overactive sympathetic nervous system that causes elevated blood pressure can instruct bone marrow stem cells to produce more white blood cells that clog up blood vessels.

“We now know that changes in the immune system contribute significantly to heart disease. We aimed to determine how the sympathetic nervous system through the brain directly promotes atherosclerosis in the setting of hypertension. We have discovered that this form of high blood pressure, often associated with stress, causes changes within the bone marrow leading to increased white blood cells circulating though our vessels. This is significant as the general view of hypertension is that it is mainly a disease of the blood vessels, which means other heart damaging events are missed.” The team is now exploring the specific molecules involved, which may shed light as to why some current therapies are ineffective.

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated blood pressure. We aimed to determine how the sympathetic nervous system directly promotes atherosclerosis in the setting of hypertension. We used a mouse model of sympathetic nervous system-driven hypertension on the atherosclerotic-prone apolipoprotein E deficient background. When mice were placed on a western type diet for 16 weeks we showed the evolution of unstable atherosclerotic lesions. Fortuitously, the changes in lesion composition were independent of endothelial dysfunction, allowing for the discovery of alternative mechanisms.

With the use of flow cytometry and bone marrow imaging, we found that sympathetic activation caused deterioration of the hematopoietic stem and progenitor cell niche in the bone marrow, promoting the liberation of these cells into the circulation and extramedullary hematopoiesis in the spleen. Specifically, sympathetic activation reduced the abundance of key hematopoietic stem and progenitor cell niche cells, sinusoidal endothelial cells, and osteoblasts. Additionally, sympathetic bone marrow activity prompted neutrophils to secrete proteases to cleave the hematopoietic stem and progenitor cell surface receptor CXCR4. All these effects could be reversed using the β-blocker propranolol during the feeding period. These findings suggest that elevated blood pressure driven by the sympathetic nervous system can influence mechanisms that modulate the hematopoietic system to promote atherosclerosis and contribute to cardiovascular events.

Nearly 1 In 10 in U.S. Battle Sexual Urges

Source: https://www.webmd.com/sexual-conditions/news/20181109/nearly-1-in-10-in-us-battle-sexual-urges?src=RSS_PUBLIC

650x350_spice-sex-toys

Almost 9 percent of people in the United States have distress caused by difficulty controlling their sexual feelings, urges and behaviors, new research shows.

Source: https://www.webmd.com/sexual-conditions/news/20181109/nearly-1-in-10-in-us-battle-sexual-urges?src=RSS_PUBLIC

650x350_spice-sex-toys

Almost 9 percent of people in the United States have distress caused by difficulty controlling their sexual feelings, urges and behaviors, new research shows.

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