Clonal Hematopoiesis of Indeterminate Potential (CHIP) Accelerates Chronic Kidney Disease

Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.

CHIP originated as the description of an early stage of dysfunction leading to leukemia<…

Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.

CHIP originated as the description of an early stage of dysfunction leading to leukemia<…

11 Simple Ways to Nurture Meaningful Connections Offline

Source https://tinybuddha.com/blog/11-simple-ways-to-nurture-meaningful-connections-offline/

“Turn off your email; turn off your phone; disconnect from the Internet; figure out a way to set limits so you can concentrate when you need to and disengage when you need to. Technology is a good servant but a bad master.” ~Gretchen Rubin

We live in truly extraordinary times. Where once letters and telegrams took days to reach the other side of the world, we can now send messages and emails at the push of a button; and social media has allowed us to connect with people from diverse backgrounds, helping us learn, grow, and aim for the stars.

The advancements in technology and science have afforded us such a vast array of benefits that it’s hard to argue with their cons. Yet our relationships, the very fabric of huma…

Source https://tinybuddha.com/blog/11-simple-ways-to-nurture-meaningful-connections-offline/

“Turn off your email; turn off your phone; disconnect from the Internet; figure out a way to set limits so you can concentrate when you need to and disengage when you need to. Technology is a good servant but a bad master.” ~Gretchen Rubin

We live in truly extraordinary times. Where once letters and telegrams took days to reach the other side of the world, we can now send messages and emails at the push of a button; and social media has allowed us to connect with people from diverse backgrounds, helping us learn, grow, and aim for the stars.

The advancements in technology and science have afforded us such a vast array of benefits that it’s hard to argue with their cons. Yet our relationships, the very fabric of huma…

Exploring the Biochemistry of Aortic Aneurysm Formation

Source https://www.fightaging.org/archives/2024/07/exploring-the-biochemistry-of-aortic-aneurysm-formation/

An aneurysm is a weakened section of a major blood vessel that expands and grows into a balloon-like structure. Rupture is often fatal. Aneurysms tend to form in specific locations, and researchers here ask why this is the case. Associating a characteristic set of changes in cell biochemistry with the formation of aneurysms in mice is a first step on a long road towards better detailed understanding of the mechanisms involved, and the development of interventions to prevent formation of aneurysms.

A vascular dilatation in the aorta can be life-threatening if it bursts. These so-called aortic aneurysms typically form in the same sites of the large blood vessel: either on the upper arch or in the <a href="https://en.wikipedia.org/wiki/Ab…

Source https://www.fightaging.org/archives/2024/07/exploring-the-biochemistry-of-aortic-aneurysm-formation/

An aneurysm is a weakened section of a major blood vessel that expands and grows into a balloon-like structure. Rupture is often fatal. Aneurysms tend to form in specific locations, and researchers here ask why this is the case. Associating a characteristic set of changes in cell biochemistry with the formation of aneurysms in mice is a first step on a long road towards better detailed understanding of the mechanisms involved, and the development of interventions to prevent formation of aneurysms.

A vascular dilatation in the aorta can be life-threatening if it bursts. These so-called aortic aneurysms typically form in the same sites of the large blood vessel: either on the upper arch or in the <a href="https://en.wikipedia.org/wiki/Ab…

Extracellular Vesicle Therapy Promotes Bone Formation in a Mouse Model of Osteoporosis

Source https://www.fightaging.org/archives/2024/07/extracellular-vesicle-therapy-promotes-bone-formation-in-a-mouse-model-of-osteoporosis/

Extracellular vesicles for use in therapy can be derived from engineered cells in order to adjust their contents in favorable ways. Here, researchers derive vesicles from genetically engineered osteoblasts in order to promote bone formation in a mouse model of osteoporosis. Osteoporosis is the name given to the age-related loss of bone mineral density. Bone is constantly remodeled, deposited by osteoblast cells and removed by osteoclast cells. In youth these activities are balanced, but the molecular damage of aging produces changes that favor osteoclasts. The result is a steady loss of bone density, leading to brittle, fracture-prone bones. Any approach that restores the balance betw…

Source https://www.fightaging.org/archives/2024/07/extracellular-vesicle-therapy-promotes-bone-formation-in-a-mouse-model-of-osteoporosis/

Extracellular vesicles for use in therapy can be derived from engineered cells in order to adjust their contents in favorable ways. Here, researchers derive vesicles from genetically engineered osteoblasts in order to promote bone formation in a mouse model of osteoporosis. Osteoporosis is the name given to the age-related loss of bone mineral density. Bone is constantly remodeled, deposited by osteoblast cells and removed by osteoclast cells. In youth these activities are balanced, but the molecular damage of aging produces changes that favor osteoclasts. The result is a steady loss of bone density, leading to brittle, fracture-prone bones. Any approach that restores the balance betw…

Unbusy

Source https://www.theminimalists.com/unbusy/

By Joshua Fields Millburn ·

Busy is the filthiest four-letter word.
Yet it is treated as a badge of honor,
a status symbol,
not unlike the logo
on a designer handbag
or the branding on a luxury car.

Branding: how apropos.
You are a body
branded with busyness—
a busybody.

Source https://www.theminimalists.com/unbusy/

By Joshua Fields Millburn ·

Busy is the filthiest four-letter word.
Yet it is treated as a badge of honor,
a status symbol,
not unlike the logo
on a designer handbag
or the branding on a luxury car.

Branding: how apropos.
You are a body
branded with busyness—
a busybody.

Nancey, 63 – Pivot to Fitness

Source https://seniorplanet.org/articles-sponsored-athletes-nancey-pivot/

When you want to work out, but your body has other ideas, what do you do? Senior Planet Sponsored Athlete Nancey Walker shares her key to movement and motivation.

The post Nancey, 63 – Pivot to Fitness appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-sponsored-athletes-nancey-pivot/

When you want to work out, but your body has other ideas, what do you do? Senior Planet Sponsored Athlete Nancey Walker shares her key to movement and motivation.

The post Nancey, 63 – Pivot to Fitness appeared first on Senior Planet from AARP.

Investors and providers must transform AgeTech market from products into suites

Source https://www.ageinplacetech.com/blog/investors-and-providers-must-transform-agetech-market-products-suites

The population is aging – and still, the tech solution market is immature.  Investors of all types demonstrate interest in a product here and an offering there.  Competitions highlight product winners; money is raised for one product at a time.  One reason for the immaturity of the market is the behavior of buyers. Senior living companies buy a product for this and an offering for that. The future is predicted to incorporate new technology like AI – but that is always …

Source https://www.ageinplacetech.com/blog/investors-and-providers-must-transform-agetech-market-products-suites

The population is aging – and still, the tech solution market is immature.  Investors of all types demonstrate interest in a product here and an offering there.  Competitions highlight product winners; money is raised for one product at a time.  One reason for the immaturity of the market is the behavior of buyers. Senior living companies buy a product for this and an offering for that. The future is predicted to incorporate new technology like AI – but that is always …

Notes on the 2024 Longevity Summit Dublin

Source https://www.fightaging.org/archives/2024/07/notes-on-the-2024-longevity-summit-dublin/

I attended this year’s Longevity Summit Dublin in June, hosted by the Longevity Escape Velocity (LEV) Foundation folk, but was so buried in work that there was no chance I would be able to take comprehensive notes for later formatting into a post here. Fortunately there are a good number of patient advocates in the community who can do just as good a job as I might, were I less encumbered, and thus Lifespan.io has published notes on some of the highlights from the conference.

The Longevity Summit Dublin is, if you like, the spiritual successor to the Strategies for Engineered Negligible Senescence (SENS) conference series of past years: scientists presenting novel research aimed at the goal of treating aging as a medical condition; biotech startups showcasing their programs of development relevant to the treatme…

Source https://www.fightaging.org/archives/2024/07/notes-on-the-2024-longevity-summit-dublin/

I attended this year’s Longevity Summit Dublin in June, hosted by the Longevity Escape Velocity (LEV) Foundation folk, but was so buried in work that there was no chance I would be able to take comprehensive notes for later formatting into a post here. Fortunately there are a good number of patient advocates in the community who can do just as good a job as I might, were I less encumbered, and thus Lifespan.io has published notes on some of the highlights from the conference.

The Longevity Summit Dublin is, if you like, the spiritual successor to the Strategies for Engineered Negligible Senescence (SENS) conference series of past years: scientists presenting novel research aimed at the goal of treating aging as a medical condition; biotech startups showcasing their programs of development relevant to the treatme…

Senior Planet Launches Saturday Classes

Source https://seniorplanet.org/articles-senior-planet-weekend-classes/

Senior Planet has started offering Saturday classes online!

The post Senior Planet Launches Saturday Classes appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-senior-planet-weekend-classes/

Senior Planet has started offering Saturday classes online!

The post Senior Planet Launches Saturday Classes appeared first on Senior Planet from AARP.

The Amazing Power of Listening to Your Inner Critic

Source https://tinybuddha.com/blog/the-amazing-power-of-listening-to-your-inner-critic/

“Knowing yourself is the beginning of all wisdom.” ~Aristotle

Over the past few years, I began to feel a shift in my career. Despite spending years earning certifications and degrees and building skills, my work no longer felt meaningful.

As I contemplated a change, a persistent thought echoed in my mind: “Why can’t you just be grateful for what you have?” I had many things to be grateful for, yet I wasn’t happy and constantly judged myself for it. After months of unsuccessfully trying to push this thought away, I decided to sit with the feeling of guilt and approach it with curiosity.

Here’s what I discovered: This was actually an <a href="https://tinybu…

Source https://tinybuddha.com/blog/the-amazing-power-of-listening-to-your-inner-critic/

“Knowing yourself is the beginning of all wisdom.” ~Aristotle

Over the past few years, I began to feel a shift in my career. Despite spending years earning certifications and degrees and building skills, my work no longer felt meaningful.

As I contemplated a change, a persistent thought echoed in my mind: “Why can’t you just be grateful for what you have?” I had many things to be grateful for, yet I wasn’t happy and constantly judged myself for it. After months of unsuccessfully trying to push this thought away, I decided to sit with the feeling of guilt and approach it with curiosity.

Here’s what I discovered: This was actually an <a href="https://tinybu…

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