Ulcerative colitis is an inflammatory bowel disease (IBD) that’s caused by an overactive immune system. Having UC doesn’t increase your risk of COVID-19. However, it might make COVID-19 symptoms and complications more severe.
Ulcerative colitis is an inflammatory bowel disease (IBD) that’s caused by an overactive immune system. Having UC doesn’t increase your risk of COVID-19. However, it might make COVID-19 symptoms and complications more severe.
Senescent cells accumulate with age, and that accumulation is responsible for a meaningful fraction of degenerative aging. Many groups are working on ways to remove these cells and thereby reverse aspects of aging. Among their number, Cleara Biotech was founded four years ago on to advance initially promising work on the FOXO4-p53 interaction in cellular senescence, a possible targeted way to destroy senescent cells. This approach will join the numerous other mechanisms already being exploited as the basis for pot…
Senescent cells accumulate with age, and that accumulation is responsible for a meaningful fraction of degenerative aging. Many groups are working on ways to remove these cells and thereby reverse aspects of aging. Among their number, Cleara Biotech was founded four years ago on to advance initially promising work on the FOXO4-p53 interaction in cellular senescence, a possible targeted way to destroy senescent cells. This approach will join the numerous other mechanisms already being exploited as the basis for pot…
Whether someone has intentionally deceived you for their own pleasure or you’ve had a roommate eat the last of the homemade lasagna without apologizing, you’ve experienced sociopathic behavior. Fortunately, your selfish roommate likely isn’t an actual sociopath (though they are rude AF).
While commonly known as sociopathy, antisocial personality disorder (ASPD) occurs in 1 to 4 percent of the population. Men are 3 to 5 times more likely to be diagnosed with ASPD (“and all of ’em dated me!”, an edgy Cathy cartoon would say).
Whether someone has intentionally deceived you for their own pleasure or you’ve had a roommate eat the last of the homemade lasagna without apologizing, you’ve experienced sociopathic behavior. Fortunately, your selfish roommate likely isn’t an actual sociopath (though they are rude AF).
While commonly known as sociopathy, antisocial personality disorder (ASPD) occurs in 1 to 4 percent of the population. Men are 3 to 5 times more likely to be diagnosed with ASPD (“and all of ’em dated me!”, an edgy Cathy cartoon would say).
Stress can mess with everything from your sleep to your skin. Learn the signs of a stressed face, plus how to get your glow back.
Feeling stressed? The pent-up tension, frustration, and anxiety affect more than just your brain. Stress can show up on your face too.
While some stress is a normal part of a changing life — even good changes! — chronic stress can devastate your health, from restless sleep to random breakouts.
Wanna know all the ways stress can affect your face? Let’s take a look, then figure out what you can do to release the tension and calm your complexion.
Stress can mess with everything from your sleep to your skin. Learn the signs of a stressed face, plus how to get your glow back.
Feeling stressed? The pent-up tension, frustration, and anxiety affect more than just your brain. Stress can show up on your face too.
While some stress is a normal part of a changing life — even good changes! — chronic stress can devastate your health, from restless sleep to random breakouts.
Wanna know all the ways stress can affect your face? Let’s take a look, then figure out what you can do to release the tension and calm your complexion.
A dusting of freckles on your face is so desirable these days that people use makeup, henna, and even tattoos to mimic them. But if you’d rather nix yours, that’s your prerogative. (Just take it from Britt.)
A dusting of freckles on your face is so desirable these days that people use makeup, henna, and even tattoos to mimic them. But if you’d rather nix yours, that’s your prerogative. (Just take it from Britt.)
The article here notes that researchers find cognitively healthy centenarians exhibit levels of protein aggregation and other brain lesions typical of people showing symptoms of neurodegenerative diseases. They are in some way more resistant, but why this is the case is a continuing research project. It is possible to identify specific gene variants and more youthful gene expression for some genes in cognitively healthy older individuals, but it is long trek from that data to an understanding of the mechanisms involved.
Researchers initially aimed to recruit 500 cognitively healthy centenarians. As of June 2021, 406 had signed up. Their average age when they joined was 1…
The article here notes that researchers find cognitively healthy centenarians exhibit levels of protein aggregation and other brain lesions typical of people showing symptoms of neurodegenerative diseases. They are in some way more resistant, but why this is the case is a continuing research project. It is possible to identify specific gene variants and more youthful gene expression for some genes in cognitively healthy older individuals, but it is long trek from that data to an understanding of the mechanisms involved.
Researchers initially aimed to recruit 500 cognitively healthy centenarians. As of June 2021, 406 had signed up. Their average age when they joined was 1…
To what degree do genetic variants drive the observed differences in human life expectancy? The old consensus guesstimate was that environment determines 75% of life expectancy, and genetic variants the other 25%. Further, it is the common wisdom that gene variants become more important to life expectancy in later life, either by providing greater resilience to specific forms of damage and dysfunction, or slowing the pace at which that damage and dysfunction accumulates. A great deal of medical research is based on the insight that gene variants are thought to provide on disease processes.
Views on genetic variants are changing, however. Modern research that makes use of genetic databases that cover very large populations is trending in the direction of demonstrating that <a href="https://www.fightaging.org/archives/2019/08/the-genetics-of-human-longevity-in-a-nutshell-only-a-few-identified-variants-and-ever…
To what degree do genetic variants drive the observed differences in human life expectancy? The old consensus guesstimate was that environment determines 75% of life expectancy, and genetic variants the other 25%. Further, it is the common wisdom that gene variants become more important to life expectancy in later life, either by providing greater resilience to specific forms of damage and dysfunction, or slowing the pace at which that damage and dysfunction accumulates. A great deal of medical research is based on the insight that gene variants are thought to provide on disease processes.
Views on genetic variants are changing, however. Modern research that makes use of genetic databases that cover very large populations is trending in the direction of demonstrating that <a href="https://www.fightaging.org/archives/2019/08/the-genetics-of-human-longevity-in-a-nutshell-only-a-few-identified-variants-and-ever…
If you go by looks alone, it’s fair to wonder exactly what is the difference between plantains and bananas. But though they may look similar — and it’s totally possible to use these two peel-able treats interchangeably in some recipes — plantains aren’t just bananas in different pajamas.
Here’s how to tell these two related (but delightfully unique) fruits apart.
Similarities and differences
Both plantains and bananas come from plants belonging to the genus musa, a family of heat-lovin…
If you go by looks alone, it’s fair to wonder exactly what is the difference between plantains and bananas. But though they may look similar — and it’s totally possible to use these two peel-able treats interchangeably in some recipes — plantains aren’t just bananas in different pajamas.
Here’s how to tell these two related (but delightfully unique) fruits apart.
Similarities and differences
Both plantains and bananas come from plants belonging to the genus musa, a family of heat-lovin…
Allostatic load is a compound measure of stress on the body, usually including an emphasis on inflammatory activity in the immune system. The measures making up allostatic load are raised by psychological stress, chronic exposure to pathogens or pollutants, and similar circumstances. Researchers here note that this, perhaps unsurprisingly, correlates with increased cancer mortality. Greater inflammation produces a more hospitable environment for cancer to occur and then grow, and the relationship between allostatic load and cancer may indeed be largely determined by the state of the immune system.
Allostatic load attempts to quantify physiological stress by measuring biomarkers across cardiovascular, immune, and <a hr…
Allostatic load is a compound measure of stress on the body, usually including an emphasis on inflammatory activity in the immune system. The measures making up allostatic load are raised by psychological stress, chronic exposure to pathogens or pollutants, and similar circumstances. Researchers here note that this, perhaps unsurprisingly, correlates with increased cancer mortality. Greater inflammation produces a more hospitable environment for cancer to occur and then grow, and the relationship between allostatic load and cancer may indeed be largely determined by the state of the immune system.
Allostatic load attempts to quantify physiological stress by measuring biomarkers across cardiovascular, immune, and <a hr…
Established cancers aggressively manipulate the immune system to their advantage, co-opting innate and adaptive immune cells to support rather than attack a tumor. Researchers here note a mechanism by which cancerous tissue forces T cells into a senescent state. Inhibiting this transition makes the immune system more effective at attacking the cancer, where fired up by a suitable immunotherapy that overcomes other barriers that the cancer puts in place to suppress the immune response.
It is now recognized that T cell functional state in the <a href="https://en.wikipedia.org/wiki/Tumor_microenvi…
Established cancers aggressively manipulate the immune system to their advantage, co-opting innate and adaptive immune cells to support rather than attack a tumor. Researchers here note a mechanism by which cancerous tissue forces T cells into a senescent state. Inhibiting this transition makes the immune system more effective at attacking the cancer, where fired up by a suitable immunotherapy that overcomes other barriers that the cancer puts in place to suppress the immune response.
It is now recognized that T cell functional state in the <a href="https://en.wikipedia.org/wiki/Tumor_microenvi…
