A Form of PDGF Suppresses Cellular Senescence in Intervertebral Disc Degeneration

Source https://www.fightaging.org/archives/2025/07/a-form-of-pdgf-suppresses-cellular-senescence-in-intervertebral-disc-degeneration/

Senescent cells generate inflammatory signaling that is disruptive to tissue structure and function when sustained for the long term. The lingering presence of senescent cells is considered a driving mechanism for many inflammatory conditions, including intervertebral disc degeneration. Here, researchers demonstrate in cell models that recombinant PDGF can be used to suppress the markers of the presence of cellular senescence, though it remains to be seen as to whether it achieves this outcome by destroying senescent cells, reprogramming them, or preventing their creation.

Low back pain (LBP), ranked as the first cause of year…

Source https://www.fightaging.org/archives/2025/07/a-form-of-pdgf-suppresses-cellular-senescence-in-intervertebral-disc-degeneration/

Senescent cells generate inflammatory signaling that is disruptive to tissue structure and function when sustained for the long term. The lingering presence of senescent cells is considered a driving mechanism for many inflammatory conditions, including intervertebral disc degeneration. Here, researchers demonstrate in cell models that recombinant PDGF can be used to suppress the markers of the presence of cellular senescence, though it remains to be seen as to whether it achieves this outcome by destroying senescent cells, reprogramming them, or preventing their creation.

Low back pain (LBP), ranked as the first cause of year…

What Do You Think?

comments

Translate »