Parkinson’s disease is characterized by the spread and aggregation of misfolded α-synuclein, toxic to neurons and the cause of motor neuron loss. A misfolded molecule of α-synuclein encourages other α-synuclein molecules to also misfold in the same way, and the dysfunction spreads slowly from neuron to neuron. When present in a neuron, misfolded α-synuclein will appear inside the extracellular vesicles, such as exosomes, secreted by that cell. Some of these vesicles enter the circulatory system<…
A Signature of α-synuclein in Neural Exosomes from a Blood Samples
Parkinson’s disease is characterized by the spread and aggregation of misfolded α-synuclein, toxic to neurons and the cause of motor neuron loss. A misfolded molecule of α-synuclein encourages other α-synuclein molecules to also misfold in the same way, and the dysfunction spreads slowly from neuron to neuron. When present in a neuron, misfolded α-synuclein will appear inside the extracellular vesicles, such as exosomes, secreted by that cell. Some of these vesicles enter the circulatory system<…