A Transcriptomic Map of Age-Related Loss of Muscle Regenerative Capacity

Source https://www.fightaging.org/archives/2024/12/a-transcriptomic-map-of-age-related-loss-of-muscle-regenerative-capacity/

Researchers here produce a map of transcription in muscle regeneration in mice of various ages, separated by cell type and time following muscle injury. The results are interesting, and show that the participation of the immune system in regeneration becomes dysregulated in older animals. Muscle stem cell function also declines, as might be expected. Restoring the aged immune system and aged stem cell populations are both sizable challenges facing those intent on developing the first rejuvenation therapies, but clearly very important.

The immune, stromal, and <a href="https…

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