ACBP Expression Contributes to Degenerative Aging

Source https://www.fightaging.org/archives/2025/07/acbp-expression-contributes-to-degenerative-aging/

Researchers here provide evidence for expression of the hormone ACBP to be detrimental, an accelerator of degenerative aging. Knocking down ACBP improves kidney and heart resilience in a number of circumstances, while circulating ACBP levels correlate with aspects of aging and age-related loss of function. At the present time therapies to reduce circulating levels of a given protein (such as monoclonal antibodies or forms of gene therapy targeted to the cells expressing the protein) are relatively expensive, though given a broadly beneficial use case one might imagine that costs will fall commensurate with the scale of use.

The tissue hormone <a href="htt…

Source https://www.fightaging.org/archives/2025/07/acbp-expression-contributes-to-degenerative-aging/

Researchers here provide evidence for expression of the hormone ACBP to be detrimental, an accelerator of degenerative aging. Knocking down ACBP improves kidney and heart resilience in a number of circumstances, while circulating ACBP levels correlate with aspects of aging and age-related loss of function. At the present time therapies to reduce circulating levels of a given protein (such as monoclonal antibodies or forms of gene therapy targeted to the cells expressing the protein) are relatively expensive, though given a broadly beneficial use case one might imagine that costs will fall commensurate with the scale of use.

The tissue hormone <a href="htt…

What Do You Think?

comments

Translate »