One of the many interesting questions about Alzheimer’s disease is why the relationship with being overweight or obese is tenuous in comparison to, say, type 2 diabetes. Why are there so many dramatically overweight people who do not develop Alzheimer’s disease? As researchers here note, one can clearly point to Alzheimer’s-adjacent mechanisms that obesity makes worse. Inflammatory dysfunction of the innate immune cells of the brain known as microglia has attracted a lot of attention in recent years, thought to contribute to all forms of neurodegeneration. Here, researchers look at one mechanism by whic…
ANGPTL4 and Microglial Lipid Accumulation to Link Obesity and Alzheimer's Risk
One of the many interesting questions about Alzheimer’s disease is why the relationship with being overweight or obese is tenuous in comparison to, say, type 2 diabetes. Why are there so many dramatically overweight people who do not develop Alzheimer’s disease? As researchers here note, one can clearly point to Alzheimer’s-adjacent mechanisms that obesity makes worse. Inflammatory dysfunction of the innate immune cells of the brain known as microglia has attracted a lot of attention in recent years, thought to contribute to all forms of neurodegeneration. Here, researchers look at one mechanism by whic…