Source https://www.fightaging.org/archives/2024/11/atf3-upregulation-as-a-basis-for-restoration-of-function-in-aged-skin/
To what degree should we be enthused by programs aiming to adjust expression of genes in cells to restore function in aged tissues? Evidence from recent years is suggestive that patterns of change in gene expression arise as a consequence of repeated repair of nuclear DNA damage, even if that damage itself is harmless to the cell. Adjusting those changes in gene expression therefore seems something close to rejuvenation. To the degree that harmful changes in gene expression instead arise from maladaptive reactions to damage, it may be that there is less to gain from trying to force a more youthful pattern of gene expression – the underlying damage remains, causing whatever other issues it causes.
Any given transcript…
Source https://www.fightaging.org/archives/2024/11/atf3-upregulation-as-a-basis-for-restoration-of-function-in-aged-skin/
To what degree should we be enthused by programs aiming to adjust expression of genes in cells to restore function in aged tissues? Evidence from recent years is suggestive that patterns of change in gene expression arise as a consequence of repeated repair of nuclear DNA damage, even if that damage itself is harmless to the cell. Adjusting those changes in gene expression therefore seems something close to rejuvenation. To the degree that harmful changes in gene expression instead arise from maladaptive reactions to damage, it may be that there is less to gain from trying to force a more youthful pattern of gene expression – the underlying damage remains, causing whatever other issues it causes.
Any given transcript…
What Do You Think?
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