BCL-xL as a Longevity Gene

Source https://www.fightaging.org/archives/2020/06/bcl-xl-as-a-longevity-gene/

BCL-xL is a mitochondrial protein that acts to suppress the programmed cell death response of apoptosis, and is overexpressed in some cancers, as well as in senescent cells. Thus small molecules that bind to BCL-xL have been used as chemotherapeutics and more recently as senolytics that selectively destroy senescent cells. That removal of senescent cells is a legitimate <a href="https://www.fightaging.org/archives/2016/11/predicting-the-order-of-arrival-of-the-first-r…

Source https://www.fightaging.org/archives/2020/06/bcl-xl-as-a-longevity-gene/

BCL-xL is a mitochondrial protein that acts to suppress the programmed cell death response of apoptosis, and is overexpressed in some cancers, as well as in senescent cells. Thus small molecules that bind to BCL-xL have been used as chemotherapeutics and more recently as senolytics that selectively destroy senescent cells. That removal of senescent cells is a legitimate <a href="https://www.fightaging.org/archives/2016/11/predicting-the-order-of-arrival-of-the-first-r…

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