The endoplasmic reticulum is a cellular component involved in protein synthesis in cells, finalizing these molecules for use by folding them correctly. When the endoplasmic reticulum becomes cluttered with work in progress, or otherwise slowed down, this state is called endoplasmic reticulum stress. This triggers the unfolded protein response (UPR) to clear out any problem molecules and restore function. Researchers here show that mild endoplasmic reticulum stress and consequent UPR activation is one of the mechanisms by which calorie restriction improves health and tissue function, thereby ext…
Calorie Restriction Extends Life in Part via Endoplasmic Reticulum Hormesis
The endoplasmic reticulum is a cellular component involved in protein synthesis in cells, finalizing these molecules for use by folding them correctly. When the endoplasmic reticulum becomes cluttered with work in progress, or otherwise slowed down, this state is called endoplasmic reticulum stress. This triggers the unfolded protein response (UPR) to clear out any problem molecules and restore function. Researchers here show that mild endoplasmic reticulum stress and consequent UPR activation is one of the mechanisms by which calorie restriction improves health and tissue function, thereby ext…