Cellular Maintenance Mechanisms Struggle to Break Down TDP-43 Aggregates, Leading to Neurodegeneration

Source https://www.fightaging.org/archives/2019/08/cellular-maintenance-mechanisms-struggle-to-break-down-tdp-43-aggregates-leading-to-neurodegeneration/

The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer’s disease, the α-synuclein associated with Parkinson’s disease, and so forth. In recent years researcher…

Source https://www.fightaging.org/archives/2019/08/cellular-maintenance-mechanisms-struggle-to-break-down-tdp-43-aggregates-leading-to-neurodegeneration/

The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer’s disease, the α-synuclein associated with Parkinson’s disease, and so forth. In recent years researcher…

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