Clearance of Senescent Cells Improves Immune Cell Function in the Aged Brain

Source https://www.fightaging.org/archives/2022/10/clearance-of-senescent-cells-improves-immune-cell-function-in-the-aged-brain/

Immune cells resident to the brain become more activated and inflammatory with age. Researchers have found that at least some of these cells are senescent, generating inflammatory signaling. Clearing these cells via senolytic therapies, such as the well-established dasatinib and quercetin combination, reduces inflammation and markers of neurodegeneration in mice. In the study here, researchers instead use genetic means of selective senescent cell destruction in mice, and see s…

Source https://www.fightaging.org/archives/2022/10/clearance-of-senescent-cells-improves-immune-cell-function-in-the-aged-brain/

Immune cells resident to the brain become more activated and inflammatory with age. Researchers have found that at least some of these cells are senescent, generating inflammatory signaling. Clearing these cells via senolytic therapies, such as the well-established dasatinib and quercetin combination, reduces inflammation and markers of neurodegeneration in mice. In the study here, researchers instead use genetic means of selective senescent cell destruction in mice, and see s…

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