Dysfunctional Stem Cells Contribute to Impaired Fracture Repair in Old Age

Source https://www.fightaging.org/archives/2019/07/dysfunctional-stem-cells-contribute-to-impaired-fracture-repair-in-old-age/

Stem cells perform the vital function of supporting surrounding tissue by providing new daughter somatic cells to make up losses and take their place to maintain tissue function. This stem cell activity declines with age, however, due to a combination of intrinsic damage to these cell populations, and increasing inactivity. The latter is an evolved reaction to rising levels of damage, one that serves to reduce cancer risk in earlier old age, but at the cost of a lengthy decline into incapacity. Pick near any dysfunction of aging and it is likely that loss of stem cell activity is to some degree contributing to the outcome.

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; <a href="https://en.wikipedia.org/wiki/Mesenchymal_stem…

What Do You Think?

comments