eIF2α as a Target to Prevent T Cell Stress and Loss of Function in Cancer Immunotherapy

Source https://www.fightaging.org/archives/2022/12/eif2%CE%B1-as-a-target-to-prevent-t-cell-stress-and-loss-of-function-in-cancer-immunotherapy/

Researchers here identify eIF2α as a target for interventions that prevent T cells from shutting down after prolonged activity in a tumor environment. The stress response to extended activity is normally protective, but in this case it prevents T cells from being as effective as they might be, which contributes to an established tumor’s compromise of the immune system. This sort of approach offers the promise of improving cancer immunotherapies, increasing the damage that each T cell can do to tumor tissue.

The stress response in T cells can lead to their inability to curtail tumor growth. Researchers found that T cells exposed to the environment of solid cancers undergo a natural response to stress that shuts off their functi…

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