FTL1 Inhibition in Neurons Slows Brain Aging in Mice

Source https://www.fightaging.org/archives/2025/08/ftl1-inhibition-in-neurons-slows-brain-aging-in-mice/

Changes in the expression of countless genes takes place with aging. Some of these changes are adaptive, attempts to resist the damaged environment or compensate for other impaired functions. Many are maladaptive and actively cause harm. Researchers here identify a specific maladaptive change in expression in neurons in the brains of aged mice, an increase in FTL1 that appears to produce a range of harm that contributes to loss of cognitive function.

Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cogn…

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