Is Brain Volume Loss Following Anti-Amyloid Therapy Actually a Bad Thing?

Source https://www.fightaging.org/archives/2024/12/is-brain-volume-loss-following-anti-amyloid-therapy-actually-a-bad-thing/

That loss of brain volume is a bad thing, resulting from the loss of necessary cells, is a concept central to the research and clinical fields. It occurs in the late stages of Alzheimer’s disease as cells die and cognitive function is lost. So it is interesting to see this view challenged in the context of the recently approved amyloid-clearing immunotherapies. Is brain volume loss following treatment a function of mechanisms other than loss of cells? Is it actually a beneficial outcome? I can see it requiring a great deal more time, funding, and data to convince the broader field that this is the case.

Researchers analysed data from a dozen different trials of amyloid-targeting immunotherapy. While brain shrinkage is usually an undesirable outcome, the team found that the exce…

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