Since its discovery, there has been some interest in the longevity-associated variant of human BPIFB4. It appears to reduce inflammation and improve function in the aging heart, reducing the incidence and impact of heart disease. Of particular interest is that it improves capillary density in heart tissue; recall that capillary density declines with age. Researchers are now working towards gene therapies and protein therapies that deliver the variant BPIFB4 as a way to tre…
Longevity-Associated BPIFB4 Variant Improves Cardiomyopathy in Mice
Since its discovery, there has been some interest in the longevity-associated variant of human BPIFB4. It appears to reduce inflammation and improve function in the aging heart, reducing the incidence and impact of heart disease. Of particular interest is that it improves capillary density in heart tissue; recall that capillary density declines with age. Researchers are now working towards gene therapies and protein therapies that deliver the variant BPIFB4 as a way to tre…