Mapping the Contribution of PAI-1 to Cellular Senescence and Aging in General

Source https://www.fightaging.org/archives/2024/12/mapping-the-contribution-of-pai-1-to-cellular-senescence-and-aging-in-general/

The PAI-1 protein is generated by the SERPINE1 gene. You might recall the discovery of a small human population with a loss of function mutation in this gene and longer lives then peers without the mutation. Here researchers map the relationships between PAI-1 and cellular senescence; PAI-1 is important in enabling onset of the senescent state. The accumulation of senescent cells with age is thought to be a meaningful contribution to degenerative aging, and the longevity of the PAI-1 loss …

Source https://www.fightaging.org/archives/2024/12/mapping-the-contribution-of-pai-1-to-cellular-senescence-and-aging-in-general/

The PAI-1 protein is generated by the SERPINE1 gene. You might recall the discovery of a small human population with a loss of function mutation in this gene and longer lives then peers without the mutation. Here researchers map the relationships between PAI-1 and cellular senescence; PAI-1 is important in enabling onset of the senescent state. The accumulation of senescent cells with age is thought to be a meaningful contribution to degenerative aging, and the longevity of the PAI-1 loss …

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