Mitochondrial Dysfunction as a Contributing Cause of Dry Eye Disease

Source https://www.fightaging.org/archives/2024/11/mitochondrial-dysfunction-as-a-contributing-cause-of-dry-eye-disease/

One of the components of declining mitochondrial function throughout the body with advancing age is a reduction in mitochondrial quality control, the complex process of mitophagy responsible for recycling damaged mitochondria. Increased mitophagy has been shown to improve mitochondrial function in a number of contexts. Researchers here note the contribution of mitochondrial dysfunction to the aging of the lacrimal gland, contributing to dry eye syndrome – an underappreciated and highly unpleasant feature of aging. Improved mitophagy leads to improved lacrimal gland function, a potential basis for novel therapies.

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