Researchers here report that more recently developed second generation epigenetic clocks do in fact demonstrate correlations between accelerated epigenetic age and risk of Alzheimer’s disease. Clocks are developed from databases of the status of DNA methylation sites on the genome in people of various ages. Some of these sites tend to become more or less methylated with advancing age, allowing machine learning approaches to derive algorithms that match a pattern of methylation to a chronological age. An accelerated epigenetic age implies that an individual’s epigenetics look more like those of someone with an older chronological age. The implication is that such an individual suffers a greater bu…
Newer Epigenetic Clocks Do Demonstrate Correlations with Risk of Alzheimer's Disease
Researchers here report that more recently developed second generation epigenetic clocks do in fact demonstrate correlations between accelerated epigenetic age and risk of Alzheimer’s disease. Clocks are developed from databases of the status of DNA methylation sites on the genome in people of various ages. Some of these sites tend to become more or less methylated with advancing age, allowing machine learning approaches to derive algorithms that match a pattern of methylation to a chronological age. An accelerated epigenetic age implies that an individual’s epigenetics look more like those of someone with an older chronological age. The implication is that such an individual suffers a greater bu…