Oxidative Stress Impairs Protein Mobility in the Cell

Source https://www.fightaging.org/archives/2024/12/oxidative-stress-impairs-protein-mobility-in-the-cell/

Researchers here suggest that one of the issues arising from oxidative stress in a cell is a reduced ability for critical proteins to move about the cell to where they are needed. It is an interesting concept, but quite unclear as to what one might do about it beyond alleviating the issues that caused the oxidative stress in the first place. This is the case for much of the cellular dysfunction of aging – it is more practical to focus on the causes of dysfunction than to try to patch over it.

Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility. Normally, most proteins zip around the cell bumping into other molecules until they locate the molecule they work with or act on. The slower a protein moves, the fewer other molecules it will reach, and so the less likely it will be able to do its job. Researchers found that such protein s…

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