Source https://www.fightaging.org/archives/2022/08/pace-of-life-and-and-the-longevity-resulting-from-growth-hormone-deficiency-in-mice/
The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of us.
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Source https://www.fightaging.org/archives/2022/08/pace-of-life-and-and-the-longevity-resulting-from-growth-hormone-deficiency-in-mice/
The longest lived mice to date are those in which growth hormone signaling is disrupted, such as via growth hormone receptor knockout. While larger species tend to be longer lived, within a given mammalian species greater body size (and thus greater growth hormone activity) appears to reduce life expectancy. The effect is much more pronounced in short-lived species such as mice than in long-lived species such as our own, however. An inherited loss of function mutation in growth hormone receptor in humans produces Laron syndrome in a small population, but these individuals do not appear to live any longer than the rest of us.
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