PLX5622 Clears Inflammatory Microglia in an Alzheimer's Mouse Model

Source https://www.fightaging.org/archives/2024/12/plx5622-clears-inflammatory-microglia-in-an-alzheimers-mouse-model/

Evidence strongly suggests that the inflammatory dysfunction of the innate immune cells of the brain known as microglia contributes to neurodegenerative conditions. There is a way to clear microglia from the brain, which is the use of CSF1R inhibitors such as PLX5622. A few weeks of treatment dramatically reduce the population of microglia, which will rebuild itself within a further few weeks after treatment has stopped. Researchers have observed that the new population is <a href="https://www.fightaging.org/archives/2023/07/towards-depletion-of-…

Source https://www.fightaging.org/archives/2024/12/plx5622-clears-inflammatory-microglia-in-an-alzheimers-mouse-model/

Evidence strongly suggests that the inflammatory dysfunction of the innate immune cells of the brain known as microglia contributes to neurodegenerative conditions. There is a way to clear microglia from the brain, which is the use of CSF1R inhibitors such as PLX5622. A few weeks of treatment dramatically reduce the population of microglia, which will rebuild itself within a further few weeks after treatment has stopped. Researchers have observed that the new population is <a href="https://www.fightaging.org/archives/2023/07/towards-depletion-of-…

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