Progerin is a truncated form of lamin A, a protein needed to ensure the cell nucleus has a normal structure. In patients with Hutchinson-Gilford progeria syndrome, lamin A mutation leads to a large amounts of progerin, widespread cell dysfunction, the appearance of accelerated aging, and early mortality. In normal aging, progerin is expressed to some degree in some cells, and may or may not be significant; as in all potential contributing mechanisms of aging, it is very hard to assign the degree to which that mechanism is important relative to all of the other ongoing issues. Here, researchers provide evidence for <a href="https://en.wikipedia.or…
Progerin Expression May Play a Role in Chronic Kidney Disease
Progerin is a truncated form of lamin A, a protein needed to ensure the cell nucleus has a normal structure. In patients with Hutchinson-Gilford progeria syndrome, lamin A mutation leads to a large amounts of progerin, widespread cell dysfunction, the appearance of accelerated aging, and early mortality. In normal aging, progerin is expressed to some degree in some cells, and may or may not be significant; as in all potential contributing mechanisms of aging, it is very hard to assign the degree to which that mechanism is important relative to all of the other ongoing issues. Here, researchers provide evidence for <a href="https://en.wikipedia.or…