Progress Towards Decoupling Epigenetic Rejuvenation from Cell Identity Change in Partial Reprogramming

Source https://www.fightaging.org/archives/2022/12/progress-towards-decoupling-epigenetic-rejuvenation-from-cell-identity-change-in-partial-reprogramming/

Reprogramming cells using the Yamanaka factors produces both a reset of epigenetic patterns to a more youthful configuration and a change in cell identify. One of the primary challenges inherent in reprogramming to achieve rejuvenation is avoidance of this altered cell identity. Reprogramming isn’t an immediate switch, it is a slow process over hours to days, but a fraction of reprogrammed cells do change into induced pluripotent stem cells after some period of exposure to reprogramming factors. This is an undesirable outcome when delivering a reprogramming therapy; if new approaches can be found that do not alter cell identity, that would make reprogramming a much more viable basis for rejuvenation treatments.

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