Proposing a Liver Amyloid Hypothesis of Alzheimer's Disease

Source https://www.fightaging.org/archives/2021/09/proposing-a-liver-amyloid-hypothesis-of-alzheimers-disease/

The earliest stages of Alzheimer’s disease are characterized by increasing aggregation of misfolded amyloid-β, but there is considerable debate over the role played by amyloid-β in the onset and progression of the condition. The failure of amyloid-clearing immunotherapies to improve patient outcomes has spurred a great deal of alternative theorizing, some of which regards amyloid-β aggregation as a side-effect of other, more important processes, and some of which adjusts the details by which amyloid-β produces pathology, but retains it as a central pillar of disease onset.

Unfortunately all animal models of Alzheimer’s pathology are highly artificial, as th…

Source https://www.fightaging.org/archives/2021/09/proposing-a-liver-amyloid-hypothesis-of-alzheimers-disease/

The earliest stages of Alzheimer’s disease are characterized by increasing aggregation of misfolded amyloid-β, but there is considerable debate over the role played by amyloid-β in the onset and progression of the condition. The failure of amyloid-clearing immunotherapies to improve patient outcomes has spurred a great deal of alternative theorizing, some of which regards amyloid-β aggregation as a side-effect of other, more important processes, and some of which adjusts the details by which amyloid-β produces pathology, but retains it as a central pillar of disease onset.

Unfortunately all animal models of Alzheimer’s pathology are highly artificial, as th…

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