Source https://www.fightaging.org/archives/2025/07/protein-misfolding-is-pervasive-in-the-aging-brain/
After a protein is created in the cell, it must be folded into the right conformation in order to function correctly. A complex set of mechanisms is focused on (a) achieving correct folding and (b) removing misfolded proteins when the process fails. Research into protein misfolding is weighted heavily to the consideration of the comparatively few proteins that form solid aggregates when misfolded, largely because this is an evident and measurable form of pathology that is demonstrably a cause of pathology in conditions such as Alzheimer’s disease and the varied forms of amyloidosis. What about all of the other misfolded proteins, however, those that remain soluble? Researchers here point out that hundreds of different misfolded proteins can be fou…
Source https://www.fightaging.org/archives/2025/07/protein-misfolding-is-pervasive-in-the-aging-brain/
After a protein is created in the cell, it must be folded into the right conformation in order to function correctly. A complex set of mechanisms is focused on (a) achieving correct folding and (b) removing misfolded proteins when the process fails. Research into protein misfolding is weighted heavily to the consideration of the comparatively few proteins that form solid aggregates when misfolded, largely because this is an evident and measurable form of pathology that is demonstrably a cause of pathology in conditions such as Alzheimer’s disease and the varied forms of amyloidosis. What about all of the other misfolded proteins, however, those that remain soluble? Researchers here point out that hundreds of different misfolded proteins can be fou…
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