Reviewing the Mechanisms of Alzheimer's Disease

Source https://www.fightaging.org/archives/2020/07/reviewing-the-mechanisms-of-alzheimers-disease/

The present understanding of Alzheimer’s disease is illustrative of a broader issue with aging in general, in that while there is considerable evidence to pin down specific pathological mechanisms in cells and tissues, it is hard to prove exactly how these mechanisms interact. What is cause, what is consequence. What is important, what is merely a side-effect of other, important processes. At present there is some upheaval in the Alzheimer’s research community based on the failure of amyloid-β clearance to produce meaningful benefits in patients. This may or may not disrupt the present thinking on the condition, that early <a href="https://en.wikipedia.org/wiki/Amy…

Source https://www.fightaging.org/archives/2020/07/reviewing-the-mechanisms-of-alzheimers-disease/

The present understanding of Alzheimer’s disease is illustrative of a broader issue with aging in general, in that while there is considerable evidence to pin down specific pathological mechanisms in cells and tissues, it is hard to prove exactly how these mechanisms interact. What is cause, what is consequence. What is important, what is merely a side-effect of other, important processes. At present there is some upheaval in the Alzheimer’s research community based on the failure of amyloid-β clearance to produce meaningful benefits in patients. This may or may not disrupt the present thinking on the condition, that early <a href="https://en.wikipedia.org/wiki/Amy…

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