Reviewing What is Known of Mitochondrial Sirtuins in Aging

Source https://www.fightaging.org/archives/2025/08/reviewing-what-is-known-of-mitochondrial-sirtuins-in-aging/

The sirtuin family of proteins has attracted research interest for its involvement in mechanisms that may influence the pace of aging. While the overhyped work on the effects of sirtuin 1 on aging unraveled to produce no practical applications, sirtuin 3, sirtuin 4, and sirtuin 5 are localized in the mitochondria and there is a range of more convincing evidence to suggest that they can be manipulated to meaningfully adjust mitochondrial function in later life.

Sirtuins, colloquially termed “longevity proteins,” are central regulators in the intricate molecular netwo…

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