Klotho is well established as a longevity-associated gene. Greater expression, and thus higher circulating levels of the soluble klotho protein fragment secreted by cells, induces a longer life span in mice and correlates with a longer life span, improved function, and reduced incidence of age-related disease in humans. While the mechanisms by which klotho improves health and slows aging are far from fully cataloged and understood, a number of companies are working on therapies based on delivery of soluble klotho or upregulation of expression. Meanwhile, the research community continues to generate human data on circulating soluble klotho and health metrics in older individuals.
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Serum Klotho Correlates with Pulmonary Function in Older Adults
Klotho is well established as a longevity-associated gene. Greater expression, and thus higher circulating levels of the soluble klotho protein fragment secreted by cells, induces a longer life span in mice and correlates with a longer life span, improved function, and reduced incidence of age-related disease in humans. While the mechanisms by which klotho improves health and slows aging are far from fully cataloged and understood, a number of companies are working on therapies based on delivery of soluble klotho or upregulation of expression. Meanwhile, the research community continues to generate human data on circulating soluble klotho and health metrics in older individuals.
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