The Nucleolus as a Factor in Age-Related Loss of Proteostasis

Source https://www.fightaging.org/archives/2025/01/the-nucleolus-as-a-factor-in-age-related-loss-of-proteostasis/

The nucleolus structure of the cell is where ribosomes are built, but it appears to be influential in a range of mechanisms relating to stress response, quality control, and damage repair in cells. All of these are in turn linked to pace of aging. The relationships are by no means fully understood in detail, however. This is an area of ongoing exploration in which researchers are finding ways to adjust nucleolar function to slow aging in model organisms such as yeast and nematode worms.

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