Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span

Source https://www.fightaging.org/archives/2023/07/reviewing-what-is-known-of-the-biochemistry-of-klotho-relevant-to-effects-on-life-span/

Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number of different mechanisms. Unfortunately, klotho expression declines with age. Whether treating humans with therapies that increase levels of klotho will produce effects that are as large as those observed in mice remains to be seen. Programs that might lead to treatments remain at a preclinical stage of development, though recently advanced to the point of testing in non-human primates.

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