Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-september-1st-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-september-1st-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/08/cisd2-slows-the-age-related-dysfunction-of-heart-muscle/
Increased CISD2 expression has been shown to slow aging in mice, and is one of the few longevity-inducing genes robustly identified to date. Increased expression improves liver function, reduces senescent cell inflammatory signaling in skin, and generates a range of other beneficial effects along the way. CISD2 produces numerous changes in aspects of metabolism, including mitochondrial func…
Source https://www.fightaging.org/archives/2025/08/cisd2-slows-the-age-related-dysfunction-of-heart-muscle/
Increased CISD2 expression has been shown to slow aging in mice, and is one of the few longevity-inducing genes robustly identified to date. Increased expression improves liver function, reduces senescent cell inflammatory signaling in skin, and generates a range of other beneficial effects along the way. CISD2 produces numerous changes in aspects of metabolism, including mitochondrial func…
Source https://www.fightaging.org/archives/2025/08/an-example-of-dna-repair-deficiency-accelerating-muscle-aging/
Randomly occurring mutations to nuclear DNA accumulate with age. While DNA repair machinery in the cell nucleus has evolved to be highly efficient, nonetheless some fraction of the damage accumulated via radiation and molecular interactions slips through. There is considerable debate over the degree to which the accumulation of mutations contributes to degenerative aging, and which effects are important. Clearly mutation burden increases risk of cancer, that conclusion is solid and well supported: the more mutations, the more likely it is that a cancerous combination of mutations will occur. Going beyond this, matters become less clear, however.
The current consensus on this subject is that mutations occurring in <a href="https://en.wikipedia.org/wik…
Source https://www.fightaging.org/archives/2025/08/an-example-of-dna-repair-deficiency-accelerating-muscle-aging/
Randomly occurring mutations to nuclear DNA accumulate with age. While DNA repair machinery in the cell nucleus has evolved to be highly efficient, nonetheless some fraction of the damage accumulated via radiation and molecular interactions slips through. There is considerable debate over the degree to which the accumulation of mutations contributes to degenerative aging, and which effects are important. Clearly mutation burden increases risk of cancer, that conclusion is solid and well supported: the more mutations, the more likely it is that a cancerous combination of mutations will occur. Going beyond this, matters become less clear, however.
The current consensus on this subject is that mutations occurring in <a href="https://en.wikipedia.org/wik…
Source https://tinybuddha.com/blog/from-loss-to-hope-how-i-found-joy-again/
“Even when we fall, we rise again—a little wiser, a little braver, and with a way better story to tell.” ~Jessica W. Bowman
The phone call arrived like a silent explosion, shattering the ordinary hum of a Tuesday morning. My uncle was gone, suddenly, unexpectedly. Just a few months later, before the raw edges of that loss could even begin to soften, my mom followed. Her passing felt like a cruel echo, ripping open wounds that had barely begun to form scabs.
I remember those months as a blur of black clothes, hushed voices, and an aching emptiness that permeated every corner of my life. Grief settled over me like a suffocating blanket, heavy and constant. It wasn’t just the pain of losing them; it was the abrupt shift in …
Source https://tinybuddha.com/blog/from-loss-to-hope-how-i-found-joy-again/
“Even when we fall, we rise again—a little wiser, a little braver, and with a way better story to tell.” ~Jessica W. Bowman
The phone call arrived like a silent explosion, shattering the ordinary hum of a Tuesday morning. My uncle was gone, suddenly, unexpectedly. Just a few months later, before the raw edges of that loss could even begin to soften, my mom followed. Her passing felt like a cruel echo, ripping open wounds that had barely begun to form scabs.
I remember those months as a blur of black clothes, hushed voices, and an aching emptiness that permeated every corner of my life. Grief settled over me like a suffocating blanket, heavy and constant. It wasn’t just the pain of losing them; it was the abrupt shift in …
Source https://www.fightaging.org/archives/2025/08/mesaconic-acid-as-a-beneficial-metabolite-generated-in-the-gut-microbiome-of-centenarians/
A good deal of research interest is now focused on the composition of the gut microbiome as either (a) a contributing factor in degenerative aging, due to changes that take place with age or (b) a factor in determining natural variations in human life span. For example, a number of research groups have mapped the composition of gut microbiomes in very long-lived individuals. The study here goes a little beyond a map of species and relative population sizes to identify a metabolite produced by microbes that appears to be protective in older individuals, based on results in mice.
The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We p…
Source https://www.fightaging.org/archives/2025/08/mesaconic-acid-as-a-beneficial-metabolite-generated-in-the-gut-microbiome-of-centenarians/
A good deal of research interest is now focused on the composition of the gut microbiome as either (a) a contributing factor in degenerative aging, due to changes that take place with age or (b) a factor in determining natural variations in human life span. For example, a number of research groups have mapped the composition of gut microbiomes in very long-lived individuals. The study here goes a little beyond a map of species and relative population sizes to identify a metabolite produced by microbes that appears to be protective in older individuals, based on results in mice.
The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We p…
Source https://seniorplanet.org/articles-inspiring-leonidas-demas-filmmaker/
Leonidas Demas, retired attorney, draws on his Greek heritage to become, at 78, the first-time filmmaker of “A Spartan Dream.”
The post Inspiring Story: Leonidas Demas, First-Time Filmmaker at 78 appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-inspiring-leonidas-demas-filmmaker/
Leonidas Demas, retired attorney, draws on his Greek heritage to become, at 78, the first-time filmmaker of “A Spartan Dream.”
The post Inspiring Story: Leonidas Demas, First-Time Filmmaker at 78 appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-ed-begley-jr/
Ed Begley Jr., 75, talks about his dad, the environment, his career, how he became a cat person and his role in the new black comedy, Don’t Tell Larry.
The post Senior Planet Talks to…Ed Begley Jr. appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-ed-begley-jr/
Ed Begley Jr., 75, talks about his dad, the environment, his career, how he became a cat person and his role in the new black comedy, Don’t Tell Larry.
The post Senior Planet Talks to…Ed Begley Jr. appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/08/data-suggests-taurine-does-not-decline-with-age-in-primates/
A study from a few years ago showed that circulating taurine levels declined with age in mice, and taurine supplementation extended healthy life span. That sparked some interest in the research community in corroborating those findings. Here, researchers show that matters relating to taurine and taurine supplementation are not straightforward, as in their data sets taurine from blood samples does not decline with age, and is not straightforwardly associated with age-related issues. It remains the case that conducting a study in people with low taurine levels would be comparatively simple to carry out, albeit expensive as is the case for any clinical trial, but the choice of what to assess as an outcome is now more complex than it was.
Taurine recently gained popularity as dietary suppl…
Source https://www.fightaging.org/archives/2025/08/data-suggests-taurine-does-not-decline-with-age-in-primates/
A study from a few years ago showed that circulating taurine levels declined with age in mice, and taurine supplementation extended healthy life span. That sparked some interest in the research community in corroborating those findings. Here, researchers show that matters relating to taurine and taurine supplementation are not straightforward, as in their data sets taurine from blood samples does not decline with age, and is not straightforwardly associated with age-related issues. It remains the case that conducting a study in people with low taurine levels would be comparatively simple to carry out, albeit expensive as is the case for any clinical trial, but the choice of what to assess as an outcome is now more complex than it was.
Taurine recently gained popularity as dietary suppl…
Source https://www.ageinplacetech.com/blog/senior-care-acuity-level-rises-so-must-adoption-technology
We are selling a product that people don’t want to buy. This Senior Housing News article, The New Skilled Nursing: Assisted Living Operators Adapt to Changing Place in the Care Continuum does not hide a trend that is significantly changing their business but also the future for older adults. So they delay their move until it becomes urgent – Mom cannot live at home any longer. Translate – Mom is too frail, her dementia is worse, her mobility has declined, etc. She will need multiple types of support. Recent <a href="https://…
Source https://www.ageinplacetech.com/blog/senior-care-acuity-level-rises-so-must-adoption-technology
We are selling a product that people don’t want to buy. This Senior Housing News article, The New Skilled Nursing: Assisted Living Operators Adapt to Changing Place in the Care Continuum does not hide a trend that is significantly changing their business but also the future for older adults. So they delay their move until it becomes urgent – Mom cannot live at home any longer. Translate – Mom is too frail, her dementia is worse, her mobility has declined, etc. She will need multiple types of support. Recent <a href="https://…
Source https://tinybuddha.com/blog/coming-out-at-50-love-loss-and-living-my-truth/
“The privilege of a lifetime is to become who you truly are.” ~Carl Jung
We all had a wild ride during the pandemic, am I right? Mine included falling in love with a woman. At fifty years old.
That’s not something I expected. But isn’t that how life goes?
One day you’re baking sourdough and trying not to touch your face, and the next you’re coming out to the world and losing half your family in the process.
I’d been single for over two decades—twenty-five years of bad dates, some good therapy, and quiet Friday nights. I’d survived abuse, betrayal, and abandonment.
I’d been struggling to make peace with…
Source https://tinybuddha.com/blog/coming-out-at-50-love-loss-and-living-my-truth/
“The privilege of a lifetime is to become who you truly are.” ~Carl Jung
We all had a wild ride during the pandemic, am I right? Mine included falling in love with a woman. At fifty years old.
That’s not something I expected. But isn’t that how life goes?
One day you’re baking sourdough and trying not to touch your face, and the next you’re coming out to the world and losing half your family in the process.
I’d been single for over two decades—twenty-five years of bad dates, some good therapy, and quiet Friday nights. I’d survived abuse, betrayal, and abandonment.
I’d been struggling to make peace with…
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