Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-25th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-25th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://seniorplanet.org/articles-mancave-simplicity/
Got too much stuff, too much technology, too much consuming? Try focusing on experiences rather than material possessions.
The post The Man Cave on…Simplicity appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-mancave-simplicity/
Got too much stuff, too much technology, too much consuming? Try focusing on experiences rather than material possessions.
The post The Man Cave on…Simplicity appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/08/an-example-of-continued-efforts-to-correlate-gut-microbiome-features-with-late-life-health/
A broad range of evidence points to the composition of the gut microbiome providing a similar degree of influence on long-term health as is the case for lifestyle choices in diet and degree of physical activity. The relative proportions of microbial species making up the gut microbiome change with age, and much of this change appears unfavorable. Microbes that manufacture beneficial metabolites necessary for tissue function throughout the body decline in number, while microbes that <a href="https://www.fightaging.org/archives/2019/03/changes-in-the-gut-microbiome-as-the-cause-of-inflammation-and-oxidative-stress-lead…
Source https://www.fightaging.org/archives/2025/08/an-example-of-continued-efforts-to-correlate-gut-microbiome-features-with-late-life-health/
A broad range of evidence points to the composition of the gut microbiome providing a similar degree of influence on long-term health as is the case for lifestyle choices in diet and degree of physical activity. The relative proportions of microbial species making up the gut microbiome change with age, and much of this change appears unfavorable. Microbes that manufacture beneficial metabolites necessary for tissue function throughout the body decline in number, while microbes that <a href="https://www.fightaging.org/archives/2019/03/changes-in-the-gut-microbiome-as-the-cause-of-inflammation-and-oxidative-stress-lead…
Source https://www.fightaging.org/archives/2025/08/mechanisms-involved-in-the-acceleration-of-aging-via-persistent-infection/
Persistent infection via HIV, herpesvirus, or a range of other pathogens capable of evading or subverting the immune system might reasonably be thought of as producing accelerated aging. The dysfunction produced by these infections usually centers around the immune system, but this in turn negatively affects the function of tissues and systems throughout the body. Aging is an accumulation of damage, and persistent infection produces forms of damage that overlap with those generated during the normal course of aging. Here, researchers discuss the range of mechanisms thought to be involved.
Many models of aging assume that processes such as <a href="https://en.wikipedia.org/wiki…
Source https://www.fightaging.org/archives/2025/08/mechanisms-involved-in-the-acceleration-of-aging-via-persistent-infection/
Persistent infection via HIV, herpesvirus, or a range of other pathogens capable of evading or subverting the immune system might reasonably be thought of as producing accelerated aging. The dysfunction produced by these infections usually centers around the immune system, but this in turn negatively affects the function of tissues and systems throughout the body. Aging is an accumulation of damage, and persistent infection produces forms of damage that overlap with those generated during the normal course of aging. Here, researchers discuss the range of mechanisms thought to be involved.
Many models of aging assume that processes such as <a href="https://en.wikipedia.org/wiki…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-mechanisms-of-cardiovascular-aging/
While all tissues age into dysfunction, the primary cause of human mortality is the aging of the cardiovascular system into heart failure, stroke, and heart attack, combined with the consequences of progressively worsening cardiovascular function in other organs. The way in which cardiovascular aging manifests is well documented, and the underlying processes of aging that contribute to the observed outcomes are also fairly well understood at the high level. The challenge lies in establishing exactly how the low-level mechanisms of aging give rise to changes and loss of function in the heart and vasculature. This is a t…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-mechanisms-of-cardiovascular-aging/
While all tissues age into dysfunction, the primary cause of human mortality is the aging of the cardiovascular system into heart failure, stroke, and heart attack, combined with the consequences of progressively worsening cardiovascular function in other organs. The way in which cardiovascular aging manifests is well documented, and the underlying processes of aging that contribute to the observed outcomes are also fairly well understood at the high level. The challenge lies in establishing exactly how the low-level mechanisms of aging give rise to changes and loss of function in the heart and vasculature. This is a t…
Source https://www.fightaging.org/archives/2025/08/intranasal-oxytocin-delivery-as-an-anti-aging-treatment/
Circulating oxytocin levels decline with age, and researchers have shown that restoring oxytocin to youthful levels has beneficial effects in aged animal models. Oxytocin is produced in the hypothalamus, and thus a range of different delivery mechanisms could work to replace this source. Here, researchers use an intranasal route for the introduction of replacement oxytocin, and show that it produces the expected benefits in aged mice.
While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms…
Source https://www.fightaging.org/archives/2025/08/intranasal-oxytocin-delivery-as-an-anti-aging-treatment/
Circulating oxytocin levels decline with age, and researchers have shown that restoring oxytocin to youthful levels has beneficial effects in aged animal models. Oxytocin is produced in the hypothalamus, and thus a range of different delivery mechanisms could work to replace this source. Here, researchers use an intranasal route for the introduction of replacement oxytocin, and show that it produces the expected benefits in aged mice.
While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms…
Source https://www.fightaging.org/archives/2025/08/evidence-for-quality-of-genetic-translation-to-contribute-to-species-life-span-differences/
Translation is the process by which cells manufacture many copies of a protein from one messenger RNA sequence encoding that protein. This takes place in one of the many ribosomes present in the cell, after which a newly assembled protein is folded within the endoplasmic reticulum. Translation is important, and so has evolved to be highly efficient. Errors nonetheless occur, and are corrected by various processes that identify broken, misfolded, and other problem proteins and ensure they are broken down for recycling. Those quality assurance processes have also evolved to be highly efficient. Correctly formed proteins are ne…
Source https://www.fightaging.org/archives/2025/08/evidence-for-quality-of-genetic-translation-to-contribute-to-species-life-span-differences/
Translation is the process by which cells manufacture many copies of a protein from one messenger RNA sequence encoding that protein. This takes place in one of the many ribosomes present in the cell, after which a newly assembled protein is folded within the endoplasmic reticulum. Translation is important, and so has evolved to be highly efficient. Errors nonetheless occur, and are corrected by various processes that identify broken, misfolded, and other problem proteins and ensure they are broken down for recycling. Those quality assurance processes have also evolved to be highly efficient. Correctly formed proteins are ne…
Source https://tinybuddha.com/blog/the-questions-that-helped-me-reclaim-my-life/
“You can rewrite the story. You just have to pick up the pen.” ~Unknown
I remember the exact moment I started disappearing.
It was my wedding day. Just before I walked down the aisle, my mother gently reached for my hand and said, “Your hands are freezing!”
She was right. I was ice-cold.
At first, I laughed it off—after all, it was February in Connecticut. Cold hands made sense, right? But that day, something didn’t add up.
We were in the middle of an unusual Indian summer. The air was warm, the sun soft and golden. People were sipping champagne outside without jackets.
<p style="fon…
Source https://tinybuddha.com/blog/the-questions-that-helped-me-reclaim-my-life/
“You can rewrite the story. You just have to pick up the pen.” ~Unknown
I remember the exact moment I started disappearing.
It was my wedding day. Just before I walked down the aisle, my mother gently reached for my hand and said, “Your hands are freezing!”
She was right. I was ice-cold.
At first, I laughed it off—after all, it was February in Connecticut. Cold hands made sense, right? But that day, something didn’t add up.
We were in the middle of an unusual Indian summer. The air was warm, the sun soft and golden. People were sipping champagne outside without jackets.
<p style="fon…
Source https://tinybuddha.com/blog/why-i-learned-to-stay-quiet-to-be-good/
“Your silence will not protect you.” ~Audre Lorde
When I was little, I learned that being “good” meant being quiet.
Not just with my voice, but with my needs. My emotions. Even the space I took up.
I don’t remember anyone sitting me down and saying, “Don’t speak unless spoken to.” But I felt it—in the flinches when I was too loud, the tension when I cried, the subtle praise when I stayed calm, agreeable, small. I felt it in the way adults sighed with relief when I didn’t make a fuss. I felt it in the way I stopped asking for what I wanted.
Goodness, to me, became about not rocking the boat.
<p style="font-weight: 400…
Source https://tinybuddha.com/blog/why-i-learned-to-stay-quiet-to-be-good/
“Your silence will not protect you.” ~Audre Lorde
When I was little, I learned that being “good” meant being quiet.
Not just with my voice, but with my needs. My emotions. Even the space I took up.
I don’t remember anyone sitting me down and saying, “Don’t speak unless spoken to.” But I felt it—in the flinches when I was too loud, the tension when I cried, the subtle praise when I stayed calm, agreeable, small. I felt it in the way adults sighed with relief when I didn’t make a fuss. I felt it in the way I stopped asking for what I wanted.
Goodness, to me, became about not rocking the boat.
<p style="font-weight: 400…
Source https://www.fightaging.org/archives/2025/08/the-gut-microbiome-contributes-to-the-progression-of-heart-failure/
In recent years, research has indicated that the composition of the gut microbiome is influential on long-term heath and the progression of aging and age-related conditions, perhaps to a similar degree as the better studied influences of weight and exercise. The scientific community has made inroads into correlating specific microbial species and metabolites with specific conditions, and has demonstrated that altering the balance of populations making up the gut microbiome can improve health and extend life in aged animals. Here, researchers review what is known of the ways in which age-related changes in the composition of the gut microbiome can contribute to the progression of heart failure…
Source https://www.fightaging.org/archives/2025/08/the-gut-microbiome-contributes-to-the-progression-of-heart-failure/
In recent years, research has indicated that the composition of the gut microbiome is influential on long-term heath and the progression of aging and age-related conditions, perhaps to a similar degree as the better studied influences of weight and exercise. The scientific community has made inroads into correlating specific microbial species and metabolites with specific conditions, and has demonstrated that altering the balance of populations making up the gut microbiome can improve health and extend life in aged animals. Here, researchers review what is known of the ways in which age-related changes in the composition of the gut microbiome can contribute to the progression of heart failure…