Source https://www.fightaging.org/archives/2025/08/towards-tissue-engineered-patches-for-a-ruptured-myocardium/
In the near term, the field of tissue engineering aims to produce artificial tissue structures that can support cells and integrate with native tissue when implanted into an injury, promoting regeneration that would not otherwise have taken place. In the longer term, the goal is to produce entirely artificial, fully functional organs – but first things first. Producing large sections of pseudo-tissue that can reliably promote regeneration is still a work in progress, with many projects at varying stages of development. As this paper makes clear, the fine details involved in sufficiently replicating tissue structural properties can be a challenge.
Myocardial Infarction (MI) occurs when blood flow to the heart is restricted, causing cardiomyocyte death, scar tissue for…
Source https://www.fightaging.org/archives/2025/08/towards-tissue-engineered-patches-for-a-ruptured-myocardium/
In the near term, the field of tissue engineering aims to produce artificial tissue structures that can support cells and integrate with native tissue when implanted into an injury, promoting regeneration that would not otherwise have taken place. In the longer term, the goal is to produce entirely artificial, fully functional organs – but first things first. Producing large sections of pseudo-tissue that can reliably promote regeneration is still a work in progress, with many projects at varying stages of development. As this paper makes clear, the fine details involved in sufficiently replicating tissue structural properties can be a challenge.
Myocardial Infarction (MI) occurs when blood flow to the heart is restricted, causing cardiomyocyte death, scar tissue for…
Source https://www.nerdfitness.com/blog/stress-eating/
A couple of weeks ago, a reader sent me this question:
I exercise regularly, but I still struggle with stress eating. Where and how do I start to tackle this?
Chances are, you can relate. How do I know? 1) You’re human. (Unless you’re a robot… in which case: hi, and please don’t turn us into batteries like in The Matrix 
)
2) When we work with clients, they fill out an intake questionnair…
Source https://www.nerdfitness.com/blog/stress-eating/
A couple of weeks ago, a reader sent me this question:
I exercise regularly, but I still struggle with stress eating. Where and how do I start to tackle this?
Chances are, you can relate. How do I know? 1) You’re human. (Unless you’re a robot… in which case: hi, and please don’t turn us into batteries like in The Matrix )
2) When we work with clients, they fill out an intake questionnair…
Source https://tinybuddha.com/blog/how-i-got-free-from-the-trap-of-resentment/
“Jerry, there is some bad in the best of people and some good in the worst of people. Look for the good!” ~George Chaky, my grandfather
I was seven when he said that to me. It would later become a guiding principle in my life.
My grandfather was twenty-one when he came to the US with his older brother, Andrew. Shortly afterward, he married Maria, my grandmother, and they had five children. William, the second youngest, died at the age of seven from an illness.
One year later they lost all of their savings during the Great Depression of 1929 when many banks closed. Two years afterward, my grandmother died from a stroke at the age of thirty-six.
As I grew …
Source https://tinybuddha.com/blog/how-i-got-free-from-the-trap-of-resentment/
“Jerry, there is some bad in the best of people and some good in the worst of people. Look for the good!” ~George Chaky, my grandfather
I was seven when he said that to me. It would later become a guiding principle in my life.
My grandfather was twenty-one when he came to the US with his older brother, Andrew. Shortly afterward, he married Maria, my grandmother, and they had five children. William, the second youngest, died at the age of seven from an illness.
One year later they lost all of their savings during the Great Depression of 1929 when many banks closed. Two years afterward, my grandmother died from a stroke at the age of thirty-six.
As I grew …
Source https://www.fightaging.org/archives/2025/08/immunosenescence-framed-as-a-treatable-condition/
Immunosenescence is the name given to the age-related decline in the capacity of the immune system to carry out its duties: defend against pathogens; destroy senescent and cancerous cells; participate in normal tissue maintenance. Inflammaging, a chronic inflammatory stage characteristic of aging that arises from maladaptive reactions to damage, the presence of senescent cells, and other causes, is considered by some researchers to be an aspect of immunosenescence, while others think of it as a distinct phenotype. Both immunosenescence and inflammaging are important contributions to…
Source https://www.fightaging.org/archives/2025/08/immunosenescence-framed-as-a-treatable-condition/
Immunosenescence is the name given to the age-related decline in the capacity of the immune system to carry out its duties: defend against pathogens; destroy senescent and cancerous cells; participate in normal tissue maintenance. Inflammaging, a chronic inflammatory stage characteristic of aging that arises from maladaptive reactions to damage, the presence of senescent cells, and other causes, is considered by some researchers to be an aspect of immunosenescence, while others think of it as a distinct phenotype. Both immunosenescence and inflammaging are important contributions to…
Source https://www.fightaging.org/archives/2025/08/calorie-restriction-is-protective-in-the-context-of-chronic-kidney-disease/
The practice of calorie restriction involves eating fewer calories while still obtaining at least adequate levels of micronutrients. Mild calorie restriction might be a 10% reduction from recommended calorie levels, but as much as 40% is possible given sufficient diligence and attention to the details. Calorie restriction induces sweeping metabolic changes that collectively act to improve cell and tissue function. The present consensus is that the most important of these changes is enhanced autophagy. Autophagy is a collection of maintenance processes responsible for recycling damaged proteins and structures in the cell. In near all specie…
Source https://www.fightaging.org/archives/2025/08/calorie-restriction-is-protective-in-the-context-of-chronic-kidney-disease/
The practice of calorie restriction involves eating fewer calories while still obtaining at least adequate levels of micronutrients. Mild calorie restriction might be a 10% reduction from recommended calorie levels, but as much as 40% is possible given sufficient diligence and attention to the details. Calorie restriction induces sweeping metabolic changes that collectively act to improve cell and tissue function. The present consensus is that the most important of these changes is enhanced autophagy. Autophagy is a collection of maintenance processes responsible for recycling damaged proteins and structures in the cell. In near all specie…
Source https://seniorplanet.org/articles-senior-planet-melissa-leo/
Oscar and Emmy winning actress Melissa Leo, 64, talks about playing a detective in the new drama, The Knife, pottery, and the New York stage.
The post Senior Planet Talks to…Melissa Leo appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-senior-planet-melissa-leo/
Oscar and Emmy winning actress Melissa Leo, 64, talks about playing a detective in the new drama, The Knife, pottery, and the New York stage.
The post Senior Planet Talks to…Melissa Leo appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/pay-what-you-can-for-21-days-of-laughs-and-light/
My electric toothbrush has seen it all.
I usually look in the mirror when I’m brushing my teeth, and for a while last fall, I often cried when I stared into my own eyes.
I did my best to hold it together in front of my sons—most of the time, anyway. But the mask often cracked when I met my own gaze. Deep sobs set to the gentle hum of my sonic. Life was just that overwhelming—with medical issues, a loved one’s shock diagnosis, and countless other challenges too numerous to list.
Then one day, after months of carrying more emotional weight than I had in decades, I decided to start looking for little ways to make myself smile again. And that toothbrush became a microphone.
First it was dramatic, cathartic songs like Fix …
Source https://tinybuddha.com/blog/pay-what-you-can-for-21-days-of-laughs-and-light/
My electric toothbrush has seen it all.
I usually look in the mirror when I’m brushing my teeth, and for a while last fall, I often cried when I stared into my own eyes.
I did my best to hold it together in front of my sons—most of the time, anyway. But the mask often cracked when I met my own gaze. Deep sobs set to the gentle hum of my sonic. Life was just that overwhelming—with medical issues, a loved one’s shock diagnosis, and countless other challenges too numerous to list.
Then one day, after months of carrying more emotional weight than I had in decades, I decided to start looking for little ways to make myself smile again. And that toothbrush became a microphone.
First it was dramatic, cathartic songs like Fix …
Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
Source https://www.fightaging.org/archives/2025/08/r-loop-dna-provokes-chronic-inflammation-via-cgas-sting/
Stretches of nuclear DNA can adopt a broad range of transient structural forms, guided by the complex feedback loops of epigenetic marks, decorating molecules added to and removed from DNA. Epigenetics as a form of control over gene expression is all a matter of structure: which regions are packaged up and inaccessible, which are accessible. Other processes can also have their effects on local structure of the DNA, however. Some of the resulting structural forms can be problematic, and might be thought of as damage or dysfunction or an unwanted side-effect of those processes operating on DNA. This is all fairly well described by the scientific community, with an established nomenclature for different structural features.
In this context, an R-loop …
Source https://www.fightaging.org/archives/2025/08/urolithin-a-as-a-treatment-for-neurodegenerative-conditions/
Urolithin A is one of a number of molecules regulated as supplements that is known to modestly improve mitochondrial function. A number of companies are working on deriving drugs from modified forms of urolithin A, while the research community is more focused on trying to understand how exactly it improves mitochondrial function. The effect size is not large, as is the case for better understood approaches to improve mitochondrial function in aged tissues, such as the various ways to increase NAD+ in mitochondria, and delivery of forms of mitochondrially targeted antioxidant. These various molecules tend to produce results …
Source https://www.fightaging.org/archives/2025/08/urolithin-a-as-a-treatment-for-neurodegenerative-conditions/
Urolithin A is one of a number of molecules regulated as supplements that is known to modestly improve mitochondrial function. A number of companies are working on deriving drugs from modified forms of urolithin A, while the research community is more focused on trying to understand how exactly it improves mitochondrial function. The effect size is not large, as is the case for better understood approaches to improve mitochondrial function in aged tissues, such as the various ways to increase NAD+ in mitochondria, and delivery of forms of mitochondrially targeted antioxidant. These various molecules tend to produce results …
Source https://www.fightaging.org/archives/2025/08/reviewing-the-role-of-inflammasomes-in-aging/
Constant, unresolved inflammatory signaling is a feature of aging. It occurs in absence of the usual provocations of infection and injury, and is disruptive to tissue structure and function. Normal, short-term inflammation is useful and necessary, but long-term inflammation is harmful. It changes cell behavior for the worse, causes the normal processes of tissue maintenance to run awry, degrades the effectiveness of the immune system, encourages growth of cancers, and contributes to the onset and progression of all of the common fatal diseases of aging.
Much of this unwanted inflammation of aging is caused by the reaction of inflammasomes to the molecular damage present in an aged cell. Inflammasomes are protein complexes that evolved to react to the presence of molecules characteristic of infect…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-role-of-inflammasomes-in-aging/
Constant, unresolved inflammatory signaling is a feature of aging. It occurs in absence of the usual provocations of infection and injury, and is disruptive to tissue structure and function. Normal, short-term inflammation is useful and necessary, but long-term inflammation is harmful. It changes cell behavior for the worse, causes the normal processes of tissue maintenance to run awry, degrades the effectiveness of the immune system, encourages growth of cancers, and contributes to the onset and progression of all of the common fatal diseases of aging.
Much of this unwanted inflammation of aging is caused by the reaction of inflammasomes to the molecular damage present in an aged cell. Inflammasomes are protein complexes that evolved to react to the presence of molecules characteristic of infect…