Category: Health and Fitness

Source https://www.fightaging.org/archives/2025/08/effects-of-young-serum-factors-on-a-skin-tissue-model/

Researchers continue to search for circulating factors present in young blood fractions that might produce beneficial effects on cells in aged tissues. Transfusion of blood fractions from young donors to aged recipients has failed to produce compelling data, but it remains possible that specific factors could be manufactured and delivered in larger amounts to produce benefits. The paper here is one example of many early stage discovery projects presently taking place, in which researchers produce in vitro cell and tissue models to cost-effectively assess the effects of varied young blood fractions and specific factors. Their data suggests that factors from young blood fractions could produce benefits by altering the behavior of immune cells derived from the bone marrow that are present in tissues throughout the b…

Source https://www.fightaging.org/archives/2025/08/gfi1-inhibition-as-an-approach-to-reduce-t-cell-exhaustion/

When continually stimulated, as occurs in persistent viral infections and cancer, T cells of the adaptive immune system become exhausted. This state is characterized by an inability to attack and kill pathogens and harmful cells. As with any other aspect of the immune system, however, exhaustion is not a well-defined and simple binary state, but rather a broad category that contains many different subtypes of exhausted cell, degrees of exhaustion, and distinct biochemistries contributing to exhaustion. Cellular biochemistry is complicated at every level.

Researchers want …

Source https://www.nerdfitness.com/blog/the-genie-question/

A reader recently wrote in with a challenge that a lot of people face, even if they don’t always say it out loud:

“I want to get in shape, but I don’t know what goals to set. There’s so much out there: CrossFit, marathons, calisthenics, bodybuilding. It feels like I should want to do all of it. And I’m worried I’ll disappoint myself if I pick something and fail.”

If that resonates with you, you’re not alone.

In a world full of fitness influencers, gym ads, and shiny transformations, it’s easy to lose track of what you actually want.

So let’s zoom out and make this simp…

Source https://seniorplanet.org/articles-social-security-update-90/

Social Security turns 90 this year amid much public uncertainty about its future.

The post Social Security Update as it Hits 90 appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/08/a-bidirectional-relationship-between-aging-and-fibrotic-liver-disease/

Metabolic dysfunction-associated steatohepatitis (MASH) follows a fatty liver, largely a consequence of obesity, but made worse by aging, in which fat-induced dysfunction of liver tissue maintenance leads to an increasing burden of fibrosis and loss of function. In fibrosis, the normal mechanisms of tissue maintenance run awry and excessive collagen is deposited to form scar-like structures that disrupt tissue function. At present fibrosis is largely irreversible, despite some potentially promising lines of research and development.

In recent years, aging and cellular senescence have triggered an increased interest in correspondi…