Category: Health and Fitness

Source https://www.fightaging.org/archives/2025/08/early-life-intestinal-injury-in-fruit-flies-delays-intestinal-aging-and-mortality/

Fruit flies are used as a model of intestinal aging primarily because this aspect of aging drives mortality in that species. We can say that flies die from intestinal dysfunction in the same way that we can say that humans die from cardiovascular dysfunction; it isn’t the whole story by any means, but it is a sizable chunk of the story and the most common cause of mortality. So whenever one reads research materials on the topic of the aging of intestinal tissue, it is reasonable to expect fruit flies to be involved in that work at some point.

In today’s open access paper, researchers present an interesting finding regarding mechanisms of intes…

Source https://www.fightaging.org/archives/2025/08/potential-therapeutic-approaches-to-cerebral-small-vessel-disease/

Cerebral small vessel disease is the term given to a noteworthy level of dysfunction in the small blood vessels of the brain, a big tent category that includes endothelial dysfunction, blood-brain barrier leakage, stiffening of vessels, and the damage left by minor vessel rupture. Clinicians diagnose small vessel disease in the brain typically as a result of scans in hypertensive patients who had a stroke or exhibit cognitive dysfunction and for whom imaging shows a sizable burden of <a href="https://en.wikipedia…

Source https://tinybuddha.com/blog/how-to-enjoy-food-and-feel-good-in-your-skin/

Have you ever felt like fat and food were your enemies? Like everything would be better if you could just lose weight—and eat whatever you want without consequence?

I felt that way for much of my childhood and teens, when unresolved trauma and low self-esteem led to a long battle with food and my body.

I struggled with bulimia for over a decade, starting at twelve. And though I technically “recovered” in my early twenties, I spent years after trapped in rigid food rules and a lingering fear of eating the “wrong” thing.

It wasn’t until my thirties that I finally felt free with food and truly comfortable in my own skin.

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Source https://seniorplanet.org/articles-open-thread-not-again/

The loss of Ozzy Osbourne shortly after his farewell concert in his hometown somehow hit me harder than expected. What music icon’s passing did it to you?

The post Open Thread: “Oh no, not again!” appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/08/chronological-age-doesnt-correlate-well-with-cognitive-decline/

In today’s open access paper, researchers report on correlations between phenotypic age and cognitive function in older adults. Phenotypic age is an aging clock that uses a small number of blood chemistry measures as its inputs, such as portions of a complete blood count, creatine, C-reactive protein, and so forth. The big advantage of this approach over epigenetic clocks is that one can look at what changed following an intervention and theorize a little about what that means. Did C-reactive protein levels go down in the course of a reduction in phenotypic age, for example? That indicates positive effects on the <a href="https://www.fi…

Source https://seniorplanet.org/articles-get-done-with-ease/

Now, numerous easy-to-use digital tools help you manage tasks and keep your day running smoothly without hassle.

The post Get More Done – with Ease appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/08/mesenchymal-progenitor-cells-with-modified-foxo3-improve-health-in-aged-monkeys/

A number of variants of the FOXO3 gene are associated with greater longevity, which researchers believe may be due to an altered distribution of different forms of the FOXO3 protein. Here, researchers note a study in which a human pluripotent cell line was engineered with a favorably altered FOXO3 sequence and differentiated into mesenchymal progenitor cells. These cells were injected into aged monkeys, producing an across the board improvement in measures of health and function. This is much as one would expect from a good st…

Source https://www.fightaging.org/archives/2025/07/reviewing-the-potential-of-gene-therapies-to-treat-aging/

Here find a tour of some of the more high profile projects aimed at the production of gene therapies to treat aging. A lot more could be done than is being done, in large part because present gene therapy vectors have many limitations on the ability to effectively deliver payloads, despite ongoing improvements. They cannot deliver to the whole body in adults. They cannot deliver well to many specific organs without involving direct injections. Delivery is uneven from cell to cell in a tissue. And so forth. These problems are well understood, and many groups are attempting to produce fixes, but for now gene therapies perform well in only some circumstances. For example: permanently increasing circulating amounts of a given signal protein, since the therapy only has to affect a small number of cells in a fat pad following a <a href="https://en.wikipedia.org/wi…

Source https://www.americanspa.com/resource/brazilian-waxing-just-got-more-convenient

Brazilian Waxing Just Got More Convenient

swheeler
Tue, 04/01/2025 – 15:54

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Source https://tinybuddha.com/blog/i-lost-my-father-and-the-illusion-of-my-mother/

“Sometimes letting things go is an act of far greater power than defending or hanging on.” ~Eckhart Tolle

In July 2023, my father died in a tragic accident. We were devastated—my sisters, my mother, and I. Or so I thought.

What followed in the months after his death forced me to confront the truth of my mother’s emotional disconnection, a truth I had sensed but never fully allowed myself to see. In losing my father, I also lost the illusion of the mother I thought I had.

A Sudden Exit

By September, just two months after my father’s death, my mother packed up and left the home we had just helped her settle into. She moved from Flo…