Senescent cells accumulate in tissues throughout the body, and their collective signaling is pro-inflammatory to a significant degree. Focusing on cellular senescence in specific cell populations, such as stem cells or other critical cells in joint tissues, is a popular area of study. Adding senescent cells to a joint in mice produces degeneration, but specifically removing senescent cells from a joint using a locally injected senolytic drug doesn’t reverse degeneration in humans. This suggests that the rest of the senescent cell population in the body can continue to provide enough signaling to the jo…
Senescent Mesenchymal Stem Cells, a Target for Treating Age-Related Joint Disorders
Senescent cells accumulate in tissues throughout the body, and their collective signaling is pro-inflammatory to a significant degree. Focusing on cellular senescence in specific cell populations, such as stem cells or other critical cells in joint tissues, is a popular area of study. Adding senescent cells to a joint in mice produces degeneration, but specifically removing senescent cells from a joint using a locally injected senolytic drug doesn’t reverse degeneration in humans. This suggests that the rest of the senescent cell population in the body can continue to provide enough signaling to the jo…