Degenerative Protein Modifications in the Aging of the Brain

Source https://www.fightaging.org/archives/2020/04/degenerative-protein-modifications-in-the-aging-of-the-brain/

Researchers here discuss the connection between a declining flow of oxygen to tissues and the level of modified proteins in tissue, particularly in the brain. Modifications tend to render proteins either harmful or at the very least useless for their intended task. This affects cell function and thus also tissue function. It is an open question as to the degree to which impaired clearance versus a faster pace of creation is the important issue, but there is evidence for both to be an issue when the supply of oxygen diminishes, either abruptly due to blood vessel rupture, or more gradually due to vascular aging (loss of capillary density, heart failure, and so forth).

Proteins are the building blocks of life as they are not only the structural constituents of the living organisms but also a final func…

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