What is “The Constant” in your life?

Source https://www.nerdfitness.com/blog/the-constant/

Last week, one of the world’s most popular shows finally made its way to Netflix:

LOST.

I’m excited for more people to discover this show. Because from 2004 to 2010, I tuned into ABC each week to find out what happened to the passengers of Oceanic Flight 815.

Although it didn’t quite land the plane (heyo!) with its final few seasons, few will take umbrage with my belief that one episode in particular was one of the best hours of TV I’ve ever seen:

Season 5’s: “The Constant.”

I won’t spoil it for anybody who hasn’t seen this episode, so I’ll just speak in generalities:

A character finds himself existing within two realities inside his mind, and he’s slipping further and further from real life. It’s only through his “…

Source https://www.nerdfitness.com/blog/the-constant/

Last week, one of the world’s most popular shows finally made its way to Netflix:

LOST.

I’m excited for more people to discover this show. Because from 2004 to 2010, I tuned into ABC each week to find out what happened to the passengers of Oceanic Flight 815.

Although it didn’t quite land the plane (heyo!) with its final few seasons, few will take umbrage with my belief that one episode in particular was one of the best hours of TV I’ve ever seen:

Season 5’s: “The Constant.”

I won’t spoil it for anybody who hasn’t seen this episode, so I’ll just speak in generalities:

A character finds himself existing within two realities inside his mind, and he’s slipping further and further from real life. It’s only through his “…

Meet the Trainer: Tina Wang

Source https://seniorplanet.org/articles-trainer-tina-wang/

Meet Tina, a Senior Planet trainer of Chair Yoga, swimming enthusiast and dance and movement artist with an MFA in Visual Arts. 

The post Meet the Trainer: Tina Wang appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-trainer-tina-wang/

Meet Tina, a Senior Planet trainer of Chair Yoga, swimming enthusiast and dance and movement artist with an MFA in Visual Arts. 

The post Meet the Trainer: Tina Wang appeared first on Senior Planet from AARP.

Chronic Inflammation in Early Adulthood Correlates with Worse Cognitive Function in Middle Age

Source https://www.fightaging.org/archives/2024/07/chronic-inflammation-in-early-adulthood-correlates-with-worse-cognitive-function-in-middle-age/

Short-term inflammation is a necessary part of the immune response to pathogens, injury, and problematic cells. Lasting unresolved inflammation is harmful, however. It is a feature of aging, but can also occur to significant degrees in earlier life as a result of autoimmunity or being very overweight. Researchers here show that early adult chronic inflammation correlates with worse cognitive function nearly two decades later. One can debate the degree to which this is a measure of accelerated degenerative aging versus the progression …

Source https://www.fightaging.org/archives/2024/07/chronic-inflammation-in-early-adulthood-correlates-with-worse-cognitive-function-in-middle-age/

Short-term inflammation is a necessary part of the immune response to pathogens, injury, and problematic cells. Lasting unresolved inflammation is harmful, however. It is a feature of aging, but can also occur to significant degrees in earlier life as a result of autoimmunity or being very overweight. Researchers here show that early adult chronic inflammation correlates with worse cognitive function nearly two decades later. One can debate the degree to which this is a measure of accelerated degenerative aging versus the progression …

How to Navigate Loss and Fear and Emerge Resilient

Source https://tinybuddha.com/blog/how-to-navigate-loss-and-fear-and-emerge-resilient/

“New beginnings are often disguised as painful endings.” ~Lao Tzu

Sailing on a beautiful day in calm seas can feel like a spiritual experience and can convince your senses that life should always be like this.

My family life was smooth sailing for many years. My husband and I were committed to our family and our responsibilities of building and running our businesses, leaving little time for anything else. Gradually, the weather changed, and we found ourselves in the uncharted, turbulent waters of divorce.

I was unprepared for the toll it would take. My anxiety caused me to lose weight, and when I felt hypo-glycemic, it was my body’s reminder to nourish myself. I was scared …

Source https://tinybuddha.com/blog/how-to-navigate-loss-and-fear-and-emerge-resilient/

“New beginnings are often disguised as painful endings.” ~Lao Tzu

Sailing on a beautiful day in calm seas can feel like a spiritual experience and can convince your senses that life should always be like this.

My family life was smooth sailing for many years. My husband and I were committed to our family and our responsibilities of building and running our businesses, leaving little time for anything else. Gradually, the weather changed, and we found ourselves in the uncharted, turbulent waters of divorce.

I was unprepared for the toll it would take. My anxiety caused me to lose weight, and when I felt hypo-glycemic, it was my body’s reminder to nourish myself. I was scared …

Launching a Study of Rapamycin in Older Patients with Gum Disease

Source https://www.fightaging.org/archives/2024/07/launching-a-study-of-rapamycin-in-older-patients-with-gum-disease/

Based on the animal data, mTOR inhibition by rapamycin is the best of the presently well studied pharmacological approaches to slow aging. Rapamycin is cheap, has decades of safety data, and produces a greater extension of life span in animal models than exercise. Sad to say, but improving on the benefits of exercise remains the low bar by which we can judge and reject the vast majority of efforts to slow the progression of aging. Human studies of rapamycin in the context of aging have yet to be conducted in any extensive manner, despite a fair amount of off-label use. So it is pleasant to see that one group has recently obtained funding to conduct a study in older people with periodontal disease; the specific condition that is the target of the study is l…

Source https://www.fightaging.org/archives/2024/07/launching-a-study-of-rapamycin-in-older-patients-with-gum-disease/

Based on the animal data, mTOR inhibition by rapamycin is the best of the presently well studied pharmacological approaches to slow aging. Rapamycin is cheap, has decades of safety data, and produces a greater extension of life span in animal models than exercise. Sad to say, but improving on the benefits of exercise remains the low bar by which we can judge and reject the vast majority of efforts to slow the progression of aging. Human studies of rapamycin in the context of aging have yet to be conducted in any extensive manner, despite a fair amount of off-label use. So it is pleasant to see that one group has recently obtained funding to conduct a study in older people with periodontal disease; the specific condition that is the target of the study is l…

The Powerful Effect of Bringing Play Into Your Life

Source https://zenhabits.net/playing/

By Leo Babauta

How much of your day is spent either 1) trying to make yourself do something you really don’t want to do, or 2) avoiding doing that thing you don’t want to force yourself to do (and feeling guilty about it)?

In truth, this is most of the day for many people. Trying to coerce ourselves to do stuff.

So a few things to say about coercing ourselves:

  1. It doesn’t work really well — we’ll put up a lot of resistance if we’re trying to force ourselves.
  2. Even if you can do it, it’s super not fun!
  3. And then when you’re done forcing yourself, you have to do it again. Over and over again. Hoping to do everything “right” but usually feeling like you’re not doing it “right.”

OK, so let’s say you’re convinced that coercing yourself to do …

Source https://zenhabits.net/playing/

By Leo Babauta

How much of your day is spent either 1) trying to make yourself do something you really don’t want to do, or 2) avoiding doing that thing you don’t want to force yourself to do (and feeling guilty about it)?

In truth, this is most of the day for many people. Trying to coerce ourselves to do stuff.

So a few things to say about coercing ourselves:

  1. It doesn’t work really well — we’ll put up a lot of resistance if we’re trying to force ourselves.
  2. Even if you can do it, it’s super not fun!
  3. And then when you’re done forcing yourself, you have to do it again. Over and over again. Hoping to do everything “right” but usually feeling like you’re not doing it “right.”

OK, so let’s say you’re convinced that coercing yourself to do …

TNIK as a Potential Target for Age-Slowing Therapeutics

Source https://www.fightaging.org/archives/2024/07/tnik-as-a-potential-target-for-age-slowing-therapeutics/

The paper noted here is an illustrative snapshot of one tiny part of the search for new mechanisms of action that takes place constantly in academia and the pharmaceutical industry. Cell metabolism remains an only partially charted expanse, the high points filled in, and mostly a blank canvas in between. The poorly explored regions of metabolism could yield any number of interesting points of intervention, each a starting point for the present industry-standard approach of small molecule drug discovery. That said, there isn’t that much of an incentive to pour funds into search initiatives because the odds of success in the current paradigm are very low. The vast majority of discoveries do not lead to even marginally useful drugs. Hence there is considerable interest at the present time in the development of new computational infrastructure technologies that can reduce the cost of discovery in some way.

Source https://www.fightaging.org/archives/2024/07/tnik-as-a-potential-target-for-age-slowing-therapeutics/

The paper noted here is an illustrative snapshot of one tiny part of the search for new mechanisms of action that takes place constantly in academia and the pharmaceutical industry. Cell metabolism remains an only partially charted expanse, the high points filled in, and mostly a blank canvas in between. The poorly explored regions of metabolism could yield any number of interesting points of intervention, each a starting point for the present industry-standard approach of small molecule drug discovery. That said, there isn’t that much of an incentive to pour funds into search initiatives because the odds of success in the current paradigm are very low. The vast majority of discoveries do not lead to even marginally useful drugs. Hence there is considerable interest at the present time in the development of new computational infrastructure technologies that can reduce the cost of discovery in some way.

Increasing Either Mitochondrial Fission or Fusion Extends Life in Nematode Worms

Source https://www.fightaging.org/archives/2024/07/increasing-either-mitochondrial-fission-or-fusion-extends-life-in-nematode-worms/

The primary function of mitochondria is production of the chemical energy store molecule adenosine triphosphate (ATP) to power cell activity, though mitochondria are also integrated into many core cellular processes. Loss of mitochondrial function is an important determinant of the pace of aging, and mitochondrial dysfunction is characteristic of cells in aged tissues. A cell contains hundreds of mitochondria, these organelles descended from the first ancient symbiotic bacteria to take up residence in what would become the ancestor of all eukaryotes. Mitochondria retain an atrophied bacterial <a href="https://en.wikipedia…

Source https://www.fightaging.org/archives/2024/07/increasing-either-mitochondrial-fission-or-fusion-extends-life-in-nematode-worms/

The primary function of mitochondria is production of the chemical energy store molecule adenosine triphosphate (ATP) to power cell activity, though mitochondria are also integrated into many core cellular processes. Loss of mitochondrial function is an important determinant of the pace of aging, and mitochondrial dysfunction is characteristic of cells in aged tissues. A cell contains hundreds of mitochondria, these organelles descended from the first ancient symbiotic bacteria to take up residence in what would become the ancestor of all eukaryotes. Mitochondria retain an atrophied bacterial <a href="https://en.wikipedia…

Clonal Hematopoiesis of Indeterminate Potential (CHIP) Accelerates Chronic Kidney Disease

Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.

CHIP originated as the description of an early stage of dysfunction leading to leukemia<…

Source https://www.fightaging.org/archives/2024/07/clonal-hematopoiesis-of-indeterminate-potential-chip-accelerates-chronic-kidney-disease/

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related state in which a hematopoietic stem cell suffers a mutation that gives it and its descendants replication advantages over their peers. Mutations of this nature spread throughout cell populations in an overlapping, layered way as they occur, a form of somatic mosaicism, but occurring in hematopoietic and immune cells. Like somatic mosaicism more generally, this has the look of a problem that should cause undesirable consequences. Drawing solid connections between CHIP and specific age-related diseases is a work in progress, however.

CHIP originated as the description of an early stage of dysfunction leading to leukemia<…

11 Simple Ways to Nurture Meaningful Connections Offline

Source https://tinybuddha.com/blog/11-simple-ways-to-nurture-meaningful-connections-offline/

“Turn off your email; turn off your phone; disconnect from the Internet; figure out a way to set limits so you can concentrate when you need to and disengage when you need to. Technology is a good servant but a bad master.” ~Gretchen Rubin

We live in truly extraordinary times. Where once letters and telegrams took days to reach the other side of the world, we can now send messages and emails at the push of a button; and social media has allowed us to connect with people from diverse backgrounds, helping us learn, grow, and aim for the stars.

The advancements in technology and science have afforded us such a vast array of benefits that it’s hard to argue with their cons. Yet our relationships, the very fabric of huma…

Source https://tinybuddha.com/blog/11-simple-ways-to-nurture-meaningful-connections-offline/

“Turn off your email; turn off your phone; disconnect from the Internet; figure out a way to set limits so you can concentrate when you need to and disengage when you need to. Technology is a good servant but a bad master.” ~Gretchen Rubin

We live in truly extraordinary times. Where once letters and telegrams took days to reach the other side of the world, we can now send messages and emails at the push of a button; and social media has allowed us to connect with people from diverse backgrounds, helping us learn, grow, and aim for the stars.

The advancements in technology and science have afforded us such a vast array of benefits that it’s hard to argue with their cons. Yet our relationships, the very fabric of huma…

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