Source https://www.fightaging.org/archives/2023/12/inflammatory-mid-old-cells-in-tissues-are-restored-to-more-youthful-function-by-recombinant-slit2/
Researchers here note the existence of what they call “mid-old” cells, cells in tissue stroma that are on the path to becoming senescent, are not yet entered into the senescent state, but nonetheless produce constant inflammatory signaling that is disruptive to tissue structure and function. The researchers find that these cells respond positively to delivery of recombinant SLIT2, diminishing their bad behavior. In very old mice, this treatment resulted in improved muscle mass and function and greater animal activity. This is an interesting finding, and will need further investigation and replication to rule out other mechanisms resulting from SLIT2 delivery. For example, this behavior of mid-old cells could be <a href="https://www.fightagin…
Source https://www.fightaging.org/archives/2023/12/inflammatory-mid-old-cells-in-tissues-are-restored-to-more-youthful-function-by-recombinant-slit2/
Researchers here note the existence of what they call “mid-old” cells, cells in tissue stroma that are on the path to becoming senescent, are not yet entered into the senescent state, but nonetheless produce constant inflammatory signaling that is disruptive to tissue structure and function. The researchers find that these cells respond positively to delivery of recombinant SLIT2, diminishing their bad behavior. In very old mice, this treatment resulted in improved muscle mass and function and greater animal activity. This is an interesting finding, and will need further investigation and replication to rule out other mechanisms resulting from SLIT2 delivery. For example, this behavior of mid-old cells could be <a href="https://www.fightagin…
Source https://www.theminimalists.com/etr10/
By Joshua Fields Millburn · Follow: Facebook, Instagram
In 2012, Ryan Nicodemus and I moved from our hometown, Dayton, Ohio, to a cabin in middle-of-nowhere Montana to begin writing our second book, Everything That Remains.
After a couple years of toiling, the result was a heartrending memoir about two corporate guys who got rid of everything</em…
Source https://www.theminimalists.com/etr10/
By Joshua Fields Millburn · Follow: Facebook, Instagram
In 2012, Ryan Nicodemus and I moved from our hometown, Dayton, Ohio, to a cabin in middle-of-nowhere Montana to begin writing our second book, Everything That Remains.
After a couple years of toiling, the result was a heartrending memoir about two corporate guys who got rid of everything</em…
Source https://www.fightaging.org/archives/2023/12/isodgr-as-a-form-of-molecular-damage-contributing-to-degenerative-aging/
Proteins can become modified in a wide range of ways via addition or removal of various motifs. This is a necessary part of our biochemistry, but some modifications are harmful rather than useful. The pattern of protein modifications present in cells changes with age, and some pathological modifications begin to appear more often. The underlying reasons for these changes are usually poorly understood, at least once stepping beyond the immediate causal chemical reactions, as cellular biochemistry is very complex. As researchers here demonstrate, given a problematic modified protein that exists outside cells, it is possible to target it for removal and thereby produce benefits.
At a molecular level, aging is thought to be underpinned by progressive biomolecular damage caused by degenerative protein modifications (DPMs),…
Source https://www.fightaging.org/archives/2023/12/isodgr-as-a-form-of-molecular-damage-contributing-to-degenerative-aging/
Proteins can become modified in a wide range of ways via addition or removal of various motifs. This is a necessary part of our biochemistry, but some modifications are harmful rather than useful. The pattern of protein modifications present in cells changes with age, and some pathological modifications begin to appear more often. The underlying reasons for these changes are usually poorly understood, at least once stepping beyond the immediate causal chemical reactions, as cellular biochemistry is very complex. As researchers here demonstrate, given a problematic modified protein that exists outside cells, it is possible to target it for removal and thereby produce benefits.
At a molecular level, aging is thought to be underpinned by progressive biomolecular damage caused by degenerative protein modifications (DPMs),…
Source https://www.fightaging.org/archives/2023/12/the-effects-of-diet-on-life-expectancy/
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words “calorie”, “weight”, or “obesity”. The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging <a href="https://www.fightaging.org/archives/2020/10/visceral-fat-tissue-is-the-major-determinant-of-mortality-due-to-excess-b…
Source https://www.fightaging.org/archives/2023/12/the-effects-of-diet-on-life-expectancy/
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words “calorie”, “weight”, or “obesity”. The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging <a href="https://www.fightaging.org/archives/2020/10/visceral-fat-tissue-is-the-major-determinant-of-mortality-due-to-excess-b…
Source https://seniorplanet.org/articles-senior-planet-talent-show/
Are you a vocalist? An instrumentalist? Spoken word expert? Send audition video by 12/11 and you could be among the 19 performers in the Senior Planet Talent Show!
The post Senior Planet Talent Show! appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-senior-planet-talent-show/
Are you a vocalist? An instrumentalist? Spoken word expert? Send audition video by 12/11 and you could be among the 19 performers in the Senior Planet Talent Show!
The post Senior Planet Talent Show! appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/10-reasons-and-helpful-tips-to-make-it-a-dry-december/
“The very best thing you can do for the whole world is to make the most of yourself.” ~Wallace Wattles
In all my years of drinking, I never thought I’d hear myself suggesting a Dry December. Nor could I have predicted that the month I’d eventually decide to embrace my sober curiosity would be the holiday month.
Before I decided to give an alcohol-free lifestyle a chance, I had completed many Dry Januarys, occasional Sober Octobers, and even one Dry July. (Dry July was the hardest for me because I really felt like I was alone in trying to embrace that one.) But now I see any month as a great choice to …
Source https://tinybuddha.com/blog/10-reasons-and-helpful-tips-to-make-it-a-dry-december/
“The very best thing you can do for the whole world is to make the most of yourself.” ~Wallace Wattles
In all my years of drinking, I never thought I’d hear myself suggesting a Dry December. Nor could I have predicted that the month I’d eventually decide to embrace my sober curiosity would be the holiday month.
Before I decided to give an alcohol-free lifestyle a chance, I had completed many Dry Januarys, occasional Sober Octobers, and even one Dry July. (Dry July was the hardest for me because I really felt like I was alone in trying to embrace that one.) But now I see any month as a great choice to …
Source https://seniorplanet.org/articles-hola-senior-planet-enters-miami/
Senior Planet’s newest walk-in Center, Miami’s first technology-themed community center for older adults, opens December 4.
The post Hola! Senior Planet Enters Miami appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-hola-senior-planet-enters-miami/
Senior Planet’s newest walk-in Center, Miami’s first technology-themed community center for older adults, opens December 4.
The post Hola! Senior Planet Enters Miami appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2023/11/mild-mitochondrial-inhibition-slows-aging-in-nematode-worms/
Researchers here demonstrate that means of mildly inhibiting the production of some of the protein machinery used to generate chemical energy store molecules, adenosine triphosphate, in mitochondria can extend life by 50-70% in nematode worms – a species in which much larger life extension is possible, so this might be viewed as a moderate effect size. Many different approaches to adjusting mitochondrial function can slow aging and extend life in short-lived species. In some cases this works by provoking mitochondria into an alternative pathway for ATP generation that produces a little more oxidative stress than usual, triggering greater cell maintenance activities. The details and dosing matter, however, and there is a fine line between lesser d…
Source https://www.fightaging.org/archives/2023/11/mild-mitochondrial-inhibition-slows-aging-in-nematode-worms/
Researchers here demonstrate that means of mildly inhibiting the production of some of the protein machinery used to generate chemical energy store molecules, adenosine triphosphate, in mitochondria can extend life by 50-70% in nematode worms – a species in which much larger life extension is possible, so this might be viewed as a moderate effect size. Many different approaches to adjusting mitochondrial function can slow aging and extend life in short-lived species. In some cases this works by provoking mitochondria into an alternative pathway for ATP generation that produces a little more oxidative stress than usual, triggering greater cell maintenance activities. The details and dosing matter, however, and there is a fine line between lesser d…
Source https://www.nerdfitness.com/blog/what-is-the-30-30-30-rule-for-weight-loss/
Today, we’re diving deep into the viral 30-30-30 “rule” for weight loss.
One of the great things about working at NF, is I get to ask our team of coaches any fitness question that comes to mind.
Another perk here is I get to wear sweatpants all day.
Recently, I noticed the
Source https://www.nerdfitness.com/blog/what-is-the-30-30-30-rule-for-weight-loss/
Today, we’re diving deep into the viral 30-30-30 “rule” for weight loss.
One of the great things about working at NF, is I get to ask our team of coaches any fitness question that comes to mind.
Another perk here is I get to wear sweatpants all day.
Recently, I noticed the
Source https://www.fightaging.org/archives/2023/11/xprize-healthspan-101-million-to-incentivize-rejuvenation-in-old-people/
Prizes for success in research and development can work well, if coupled with suitable publicity and activism. Such efforts have a long history, going back to the well-documented longitude rewards offered by the British government in the 1700s. More recently, the original Ansari X Prize for suborbital flight was a very successful example of this sort of initiative, and was launched around the same time as the Methuselah Mouse Prize to spur greater efforts to extend life in animal models. The Palo Alto Longevity Prize followed later with similar goals. Unfortunately for the ability of longevity-focused prizes to generate ongoing publicity, it has turned out to be hard to beat the…
Source https://www.fightaging.org/archives/2023/11/xprize-healthspan-101-million-to-incentivize-rejuvenation-in-old-people/
Prizes for success in research and development can work well, if coupled with suitable publicity and activism. Such efforts have a long history, going back to the well-documented longitude rewards offered by the British government in the 1700s. More recently, the original Ansari X Prize for suborbital flight was a very successful example of this sort of initiative, and was launched around the same time as the Methuselah Mouse Prize to spur greater efforts to extend life in animal models. The Palo Alto Longevity Prize followed later with similar goals. Unfortunately for the ability of longevity-focused prizes to generate ongoing publicity, it has turned out to be hard to beat the…
